Evaluation of the effect of tacrolimus on periodontitis induced in rats.

Objective: This study was to investigate the effect of tacrolimus (FK506) on periodontitis induced in rats.

Design: Periodontal disease was induced in 30 Wistar rats which were then randomly divided into two groups: treatment with a daily injection of 0.9% saline (1mL/day) and treatment with a daily injection of FK506.