Congenital fibrosis of the vertically acting extraocular muscles maps to the FEOM3 locus.

The diagnosis of congenital fibrosis of the extraocular muscles (CFEOM) encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. The OMIM database (http://www.ncbi.

Central retinal vein occlusion in pseudoexfoliation of the lens capsule.

In surveying an extensive group of patients with unilateral pseudoexfoliation of the lens capsule certain interesting points emerged, particularly on the incidence of central retinal vein occlusion in this condition,and perhaps in glaucoma also. A total of 284 patients with unilateral pseudo-exfoliation of the lens capsule were examined clinically after an ophthalmic and general history were taken. Mean intraocular pressure (IOP) was 30.

Clinical features at presentation of anterior segment pigment dispersion syndrome.

One hundred and twenty patients with anterior segment pigment dispersion syndrome were reviewed in order to ascertain the features of the condition and form some idea of their significance. Patients were regarded as having pigment dispersion syndrome on the basis of heavy trabecular mesh pigmentation with at least one other feature of the condition. Although common in men, 44 patients, or a little over one-third, were women.

Management and prognosis of end-stage glaucoma.

Purpose: We followed, for a long term, end-stage glaucoma patients as defined by the level of legal blindness.

Methods: Follow up was for 7.7+/-1.

Comparison of colour Doppler imaging of orbital vessels in elderly compared with young adult patients.

Purpose: Colour Doppler imaging provides an estimate of the velocity of blood flow in vessels supplying the eye.

Methods: To assess changes in orbital blood flow with age, we used a method to study peak systolic velocity in 20 young normal patients, mean age 25.2+/-2.

A trial of dorzolamide for glaucoma.

Background And Objective: To determine whether the effectiveness of dorzolamide changes when the drug is used under routine clinical conditions versus the more ideal conditions of a clinical trial.

Patients And Methods: A total of 118 eyes of 65 patients were assessed. Nine patients (15 eyes) received dorzolamide only, 41 patients (74 eyes) received dorzolamide as an "add-on" medication, and 15 patients (29 eyes) received dorzolamide as a substitute for an oral carbonic anhydrase inhibitor.

An in-service investigation of the additive effect of topical adrenergic agonists and beta-blockers.

Background: We assessed the long-term additive effect of topical adrenaline or adrenaline precursor and beta-blockers because of doubts as to the presence and persistence of such an effect.

Methods: In 43 patents (20 males and 23 females; mean (+/- SD) age 68.4+/-11.

Effect of lens opacity on the glaucomatous field of vision.

Purpose: To assess the effect of cataract on the glaucomatous visual field.

Methods: We prospective y assessed the visual field indices of mean deviation (MD), pattern standard deviation (PSD), short-term fluctuation (SF) and corrected pattern standard deviation (CPSD) before and after cataract extraction with posterior chamber intra-ocular lens in a consecutive series of 40 patients (51 eyes) age 75.0 +/- 6.

Noninvasive closure of a persistent cyclodialysis cleft.

Background: A persistent post-traumatic cyclodialysis cleft can result in substantial visual loss due to subchoroidal effusion and macular folds with hypotony. A method of closure is needed.

Patients And Methods: After other methods had been tried, the authors used transscleral YAG laser cyclophotocoagulation in three consecutive patients with 20 applications in two rows of ten applications, 2 to 3 mm behind the limbus, at a power setting of 6 J, with a defocus setting of 9.

Disorders of perfusion of the anterior segment of the eye.

Background: We have investigated the vascular perfusion of a wide variety of conditions of the anterior segment using fluorescein angiography.

Methods: The conditions were classified and findings reported according to the system set out below. Patients underwent full ocular examination.

A clinical trial of MK-507, Trusopt, for raised intraocular pressure--the Australian experience.

Background: Since the introduction of carbonic anhydrase inhibitors, a topical preparation has been sought to avoid the complications of systemic medication while retaining the effect of lowering intraocular pressure. Recently, a topical carbonic anhydrase inhibitor, MK-507, has been found superior to others and introduced for multicentre clinical trial.

Patients And Methods: As part of an international multicentre trial, we compared MK-507 with beta blockers for one year in 20 patients with raised intraocular pressure, both as monotherapy and in combination.

Congenital fibrosis of the vertically acting extraocular muscles. A new group of dominantly inherited ocular fibrosis with radiologic findings.

Background: The authors studied a family with a form of congenital fibrosis of the extraocular muscles different from any group previously reported.

Methods: A careful examination was done of all affected and all, except one, unaffected members of a family of 15 members extending over three generations. The authors performed computed tomography on five affected and four unaffected family members.

The long-term results of fistulising trabeculotomy in chronic open-angle glaucoma.

Background: Fistulising trabeculotomy has been used for nearly 20 years to combine the minimally invasive surgery of trabeculotomy with production of a subconjunctival fistula.

Methods: The canal of Schlemm was unroofed 2mm on one side of a 3mm half-thickness scleral flap. A trabeculotomy probe was passed about 30 degrees along the canal on the opposite side and rotated into the anterior chamber.

Hypoperfusion of the iris and its consequences in anterior segment pigment dispersal syndrome.

The effects of changes in iris perfusion in anterior segment pigment dispersal syndrome (ASPDS) were examined by iris fluorescein angiography in 29 patients (20 men and 9 women; mean age, 49 +/- 14 years; range, 29 to 77 years). All showed hypoperfusion, with mild to moderate microneovascularization. There was a significant relationship between the degree of hypoperfusion and pigment scatter (P < .

The significance of anterior chamber depth in Fuchs' corneal dystrophy and cornea guttata.

It is sometimes claimed that a relationship exists between Fuchs' dystrophy and angle closure glaucoma and that this is an indication for the simultaneous performance of keratoplasty and cataract extraction in patients with Fuchs' dystrophy. If such a relationship exists, then the anterior chamber depth in Fuchs' dystrophy should resemble that in angle closure glaucoma and a significant degree of cornea guttata might be expected to be common in angle closure glaucoma. In 88 patients with angle closure glaucoma we found that the anterior chamber depth was significantly shallower than in cornea guttata or Fuchs' dystrophy for acute (p < 0.

Long-term results with argon laser trabeculoplasty.

The long-term effectiveness of argon laser trabeculoplasty (ALT) is still questioned. In order to assess the long-term effect of ALT in our hands we reviewed the results of 102 patients who underwent ALT nine to 11 years ago. Thirty eyes of 22 patients were still available for follow-up at 9.

Laser trabeculoplasty--argon or diode?

It is important to compare the pressure-lowering effect of the recently introduced diode laser with that of the argon laser currently used for trabeculoplasty, since there is a considerable difference in their wavelengths. In 50 consecutive eyes of 50 patients argon laser trabeculoplasty (ALT) produced a fall from 23 to 18 mmHg at three months compared with a fall from 23 to 19 mmHg at three months with diode laser trabeculoplasty (DLT). This difference was not statistically significant.

Hemicentral retinal vein occlusion associated with ocular hypertension and clotting abnormality.

Hemicentral retinal vein occlusion in a young adult man occurred after a high corticosteroid-induced increase in intraocular pressure (IOP), supporting the accepted association between raised IOP and retinal vein occlusion. However, detection of a plasminogen activator deficiency in this patient indicated a particular susceptibility to intravascular clotting episodes.

Progressive myopia in early onset chronic angle closure glaucoma.

A 19-year-old girl presented with advanced unilateral chronic angle closure glaucoma and myopia with gross cupping and field loss in a previously hyperopic eye with a marked increase in corneal curvature. This emphasises that a marked myopic shift may be an important sign of glaucoma in a young patient.