Publications by authors named "Gillian T Herbert"
Genetic ablation of purine salvage in reveals nucleotide uptake from the host cell.
Proc Natl Acad Sci U S A
October 2019
The apicomplexan parasite is a leading global cause of severe diarrheal disease and an important contributor to early-childhood mortality. Waterborne outbreaks occur frequently, even in countries with advanced water treatment capabilities, and there is currently no fully effective treatment. Nucleotide pathways are attractive targets for antimicrobial development, and several laboratories are designing inhibitors of these enzymes as potential treatment for infections.
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- Cryptosporidium is a major cause of diarrheal diseases, particularly affecting young children, but older kids in high-risk areas show some resistance, while unexposed adults are more vulnerable.
- Researchers developed a mouse model to study Cryptosporidium infection by isolating parasites from wild mice, which replicates human intestinal disease and reveals that T cells and interferon-γ are vital in controlling the infection.
- This mouse model allows for deeper understanding of how protective immunity works and assists in designing effective vaccines against Cryptosporidium.
Diarrhoeal disease is responsible for 8.6% of global child mortality. Recent epidemiological studies found the protozoan parasite Cryptosporidium to be a leading cause of paediatric diarrhoea, with particularly grave impact on infants and immunocompromised individuals.
View Article and Find Full Text PDFBumped kinase inhibitors (BKIs) of Cryptosporidium parvum calcium-dependent protein kinase 1 (CpCDPK1) are leading candidates for treatment of cryptosporidiosis-associated diarrhea. Potential cardiotoxicity related to anti-human ether-à-go-go potassium channel (hERG) activity of the first-generation anti-Cryptosporidium BKIs triggered further testing for efficacy. A luminescence assay adapted for high-throughput screening was used to measure inhibitory activities of BKIs against C.
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