Publications by authors named "Gillian N Petroff"
Cage effects on synaptic plasticity and its modulation in a mouse model of fragile X syndrome.
Philos Trans R Soc Lond B Biol Sci
July 2024
Article Synopsis
- Fragile X syndrome (FXS) affects executive function and memory, and this study reviews the role of breeding strategies in understanding these impairments in a mouse model.
- The research highlights significant deficits in short-term potentiation (STP), long-term potentiation (LTP), and contextual fear conditioning (CFC) in knockout (KO) mice compared to non-littermate wild-type (WT) mice, although the expression of NMDAR subunits remained unchanged.
- Notably, the effectiveness of an NMDAR modulator (UBP714) to enhance LTP induction varied based on the breeding strategy used, indicating that these strategies may cause inconsistencies in research findings related to FXS.
Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra resulting in severe and progressive motor impairments. However, the mechanisms underlying this neuronal loss remain largely unknown. Oxidative stress and ER stress have been implicated in PD and these factors are known to activate the integrated stress response (ISR).
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