The Reactive Oxygen Species-Mitophagy Signaling Pathway Regulates Liver Endothelial Cell Survival During Ischemia/Reperfusion Injury.

Ischemia/reperfusion injury (IRI) is the main cause of complications following liver transplantation. Reactive oxygen species (ROS) were thought to be the main regulators of IRI. However, recent studies demonstrate that ROS activate the cytoprotective mechanism of autophagy promoting cell survival.

B cells from patients with multiple sclerosis induce cell death via apoptosis in neurons in vitro.

B cells mediate multiple sclerosis (MS) pathogenesis by mechanisms unrelated to immunoglobulin (Ig). We reported that supernatants (Sup) from cultured B cells from blood of relapsing remitting MS (RRMS) patients, but not normal controls (NC), were cytotoxic to rat oligodendrocytes (OL). We now show that RRMS blood B cells, not stimulated in vitro, secrete factor/s toxic to rat and human neurons.

Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis.

Important antibody-independent pathogenic roles of B cells are emerging in autoimmune diseases, including multiple sclerosis (MS). The contrasting results of different treatments targeting B cells in patients (in spite of predictions of therapeutic benefits from animal models) call for a better understanding of the multiple roles that distinct human B cell responses likely play in MS. In recent years, both murine and human B cells have been identified with distinct functional properties related to their expression of particular cytokines.

The expression of neuronal sorting nexin 8 (SNX8) exacerbates abnormal cholesterol levels.

SNX8 is a PX-BAR domain sub-family of sorting nexins (SNXs), which is reported as a β-amyloid (Aβ) toxicity enhancer and associated with Alzheimer's disease. We have also described SNX8 as a novel activator of the sterol regulatory element binding protein (SREBP) transcription factor, a major regulator of cholesterol homeostasis. In that study, we have showed that SNX8 reduced an insulin-induced gene (INSIG)-dependent block of SREBP-mediated transcription.