Long-term durability and dose escalation patterns in infliximab therapy for psoriasis.

Background: Infliximab often requires dose escalation to maintain response. Studies regarding long-term durability and dose escalation patterns for psoriasis are few.

Objective: We sought to evaluate dose escalation patterns in psoriatic patients to identify factors of lack of optimal response to infliximab.

Combination use of ustekinumab with other systemic therapies: a retrospective study in a tertiary referral center.

Background: Patients with moderate to severe psoriasis may not respond adequately to single systemic agent and may require combination systemic therapy.

Objective: To evaluate the prevalence, indications, and response to combination systemic therapy with ustekinumab for psoriasis in a tertiary referral center.

Methods: This retrospective study comprised 102 psoriasis patients treated with ustekinumab at a single tertiary care center.