Staphylococcus aureus Trigger Factor Is Involved in Biofilm Formation and Cooperates with the Chaperone PpiB.

Peptidyl-prolyl isomerases (PPIases) are enzymes that assist in protein folding around proline-peptide bonds, and they often possess chaperone activity. encodes three PPIases, i.e.

Novel Regulation of Alpha-Toxin and the Phenol-Soluble Modulins by Peptidyl-Prolyl Isomerase Enzymes in .

Peptidyl-prolyl isomerases (PPIases) are enzymes that catalyze the -to- isomerization around proline bonds, allowing proteins to fold into their correct confirmation. Previously, we identified two PPIase enzymes in (PpiB and PrsA) that are involved in the regulation of virulence determinants and have shown that PpiB contributes to virulence in a murine abscess model of infection. Here, we further examine the role of these PPIases in virulence and, in particular, their regulation of hemolytic toxins.