P2X receptors and their role in female idiopathic detrusor instability.

Purpose: It is clear from previous studies that adenosine triphosphate is released as a contractile co-transmitter with acetylcholine from parasympathetic nerves supplying the mammalian bladder but the physiological significance of ligand gated purinergic P2X receptors in human bladder innervation has not been adequately investigated. We examined the role of these receptors in female patients with idiopathic detrusor instability.

Materials And Methods: Female patients with idiopathic detrusor instability were recruited for cystoscopy and bladder biopsy with ethics approval.