Publications by authors named "Gillian C Kelly"
Clin Sci (Lond)
December 2024
Article Synopsis
- * In research using mice, SCD was found to enhance vasoconstriction (narrowing of blood vessels) through the alpha-1 adrenergic receptor, particularly by increasing the expression of the alpha-1a receptor in the aortic tissue of SCD mice compared to controls.
- * Treatment with ambrisentan, an ETA receptor blocker, improved blood vessel function in both mice and SCD patients, suggesting that targeting the ET-1 pathway could help improve vascular health in individuals with
