Publications by authors named "Gillian Brennan"

Article Synopsis
  • Inhaled nitric oxide (iNO) is commonly used to treat persistent pulmonary hypertension in infants, but suddenly stopping it can cause worsening hypertension, prompting the need for a better weaning strategy.
  • A study reviewed cases of preterm infants (born before 34 weeks) who were transitioned from iNO to sildenafil, analyzing their health records from 2017 to 2021, with certain congenital conditions excluded.
  • The findings showed that sildenafil helped most infants wean off iNO successfully within days, with no reported adverse events, indicating it may be a safe and effective method for managing iNO discontinuation.
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Purpose: Current guidelines recommend debriefing following medical resuscitations to improve patient outcomes. The goal of this study was to describe national trends in postresuscitation debriefing practices among pediatric critical care medicine (PCCM) fellows to identify potential gaps in fellow education.

Methods: A 13-item survey was distributed to fellows in all 76 ACGME-accredited PCCM programs in the United States in the spring of 2021.

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Respiratory support is frequently required during neonatal transport. This review identifies the various modalities of respiratory support available during neonatal transport and their appropriate clinical uses. The respiratory equipment required during neonatal transport and appropriate safety checks are also reviewed.

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Mast cells are immune cells of hematopoietic origin that circulate as precursor cells prior to migration into vascularized tissues where they mature and undergo terminal differentiation in response to different cytokines within the local environment. Mast cells are well known as important regulators of inflammatory processes in peripheral tissues and recent studies support the involvement of mast cells in mediating the inflammatory response to cerebral hypoxia-ischemia in both the neonatal and adult brain. To better study mast cell function in vivo, it is important to be able to identify their environment-specific phenotype, as well as to study their interaction with other neural cells in vitro.

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