Publications by authors named "Gilles Paradis"

Introduction: Preeclampsia is associated with acute neurological complications during pregnancy, but the subsequent risk of developing a neurological disorder is unclear. We determined if preeclampsia was associated with the long-term risk of neurological morbidity.

Methods: We conducted a longitudinal cohort study of 1,460,098 pregnant women with and without preeclampsia in Quebec, Canada, between 1989 and 2023.

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  • This study examined how postpartum preeclampsia affects maternal and neonatal outcomes using data from over 1.3 million pregnancies in Quebec from 2006 to 2022.
  • Postpartum preeclampsia was less common than antepartum preeclampsia but was linked to higher risks of preterm birth, placental abruption, and severe maternal complications.
  • The research suggests that women who experience postpartum preeclampsia should have their blood pressure monitored for up to six weeks after delivery to identify any adverse effects.
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  • A study in Quebec examined over 1.4 million women to see if non-cardiac birth defects affect the risk of cardiovascular hospitalisation.
  • Results showed that women with any birth defect had a significantly higher rate of cardiovascular hospitalisation compared to those without defects, with non-cardiac defects increasing the risk 1.61 times.
  • Specific non-cardiac defects, especially urinary and central nervous system defects, were linked to higher risk, though cardiac defects posed the greatest risk overall.
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As there is no ranking designed for schools of Public Health, the aim of this project was to create one. To design the Public Health Academic Ranking (PHAR), we used the InCites Benchmarking and Analytics™ software and the Web Of Science™ Core Collection database. We collected bibliometric data on 26 schools of Public Health from each continent, between August and September 2022.

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The aim of this study was to examine associations of childhood physical activity, sedentary behavior, and dietary intake with adiposity trajectories from childhood to adolescence. Quebec Adipose and Lifestyle Investigation in Youth (QUALITY) cohort ( = 630) data from 3 time points (8-10, 10-12, and 15-17 years) for 377 Caucasian children with parental obesity were analyzed. Height and weight, physical activity and sedentary behavior (7-day accelerometry), screen time (self-reported), and dietary intake (three 24-hour diet recalls) were measured.

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Background: This study aimed to estimate the anti-SARS-CoV-2 antibody seroprevalence in the general population of Bobo-Dioulasso and Ouagadougou (Burkina Faso).

Methods: We collected from March to April 2021 blood samples from randomly selected residents in both main cities based on the World Health Organization (WHO) sero-epidemiological investigations protocols and tested them with WANTAI SARS-CoV-2 total antibodies enzyme-linked immunosorbent assay (ELISA) kits intended for qualitative assessment. We also recorded participants' socio-demographic and clinical characteristics and information on exposure to SARS-CoV-2.

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Background: The impact of assisted reproductive technology (ART) on the cardiovascular system is unclear.

Methods: We conducted a retrospective longitudinal cohort study of 1,001,593 pregnancies conceived naturally or through ART from 2008 to 2019 in Québec to assess the association of ART with cardiovascular disease in families. The exposure measure was ART.

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Background: Early data on COVID-19 (based primarily on PCR testing) indicated a low burden in Sub-Saharan Africa. To better understand this, this study aimed to estimate the incidence rate and identify predictors of SARS-CoV-2 seroconversion in the two largest cities of Burkina Faso. This study is part of the EmulCOVID-19 project (ANRS-COV13).

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Background: The longitudinal relation between parenting practices and styles with children's body mass index z-scores (zBMI) is poorly understood. Previous studies suggest the relationship may be complex, but small samples and short follow-ups diminish the strength of the evidence. The objectives of this study were to investigate whether the relationship is bidirectional, time-varying, and lagged using data from a large, representative birth cohort of Quebec children.

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Background: Preterm birth may affect maternal mental health, yet most studies focus on postpartum mental disorders only. We explored the relationship between preterm delivery and the long-term risk of maternal hospitalization for mental illness after pregnancy.

Methods: We performed a longitudinal cohort study of 1,381,300 women who delivered between 1989 and 2021 in Quebec, Canada, and had no prior history of mental illness.

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  • The study investigates how physical activity and sedentary behavior affects the risk of developing type 2 diabetes in children, focusing on those with a family history of obesity.
  • It utilized data from the QUALITY cohort involving children aged 8-17, measuring physical activity and screen time over multiple evaluations to assess their impact on diabetes-related health markers.
  • The findings indicated that moderate-to-vigorous physical activity had positive effects on insulin sensitivity and negative effects on insulin secretion, suggesting lifestyle factors play a significant role in diabetes risk.
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Objective: Robust evidence exists for the health-enhancing benefits of social support in adults. Inflammatory processes are thought to be an important mechanism linking social support and health risk. Less is known about the relation between social support and chronic inflammation during childhood and adolescence, or when the association emerges during the lifespan.

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Objectives: Severe obesity (SO) prevalence varies between reference curve-based definitions (WHO: ≥99th percentile, Centers for Disease Control and Prevention (CDC): >1.2×95th percentile). Whether SO definitions differentially predict cardiometabolic disease risk is critical for proper clinical care and management but is unknown.

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Introduction: Hypertension management remains a major public health challenge in primary care. Innovative interventions to improve blood pressure (BP) control are needed. One approach is through community-based models of care with the involvement of pharmacists and other non-physician healthcare professionals.

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Background: Cocaine is associated with acute cardiovascular complications, but the long-term cardiovascular risks of cocaine use are poorly understood. We examined the association between cocaine use disorders and long-term cardiovascular morbidity in women.

Methods: We analyzed a longitudinal cohort of 1,296,463 women in Quebec, Canada between 1989 and 2020.

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Introduction: We assessed change in substance use from before to during the COVID-19 pandemic in young adults and identified factors associated with initiation/increase in use.

Methods: The sample comprised young adults from a longitudinal investigation of 1294 youth recruited at ages 12-13 (1999-2000) in 10 Montréal-area high schools. Pre-pandemic data on use of cannabis, alcohol, combustible cigarette, e-cigarette and binge drinking were collected at ages 20.

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Background: Severe maternal morbidity is rising, yet the association with cardiovascular disease is not clear. We examined the risk of cardiovascular hospitalization up to 3 decades after having a pregnancy complicated by severe maternal morbidity.

Methods: We analyzed a longitudinal cohort of 1 336 846 women who were pregnant between 1989 and 2019 in Quebec, Canada.

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Background/objective: Adiposity may mediate the effect of dietary glycemic load (GL) on lipid profiles in children, as studies have shown an association between dietary GL and adiposity and between adiposity and lipid profiles. Our objective was to evaluate the role of adiposity as a mediator in the association between dietary GL and lipid profiles after 2 years.

Subjects/methods: The Quebec Adipose and Lifestyle InvesTigation in Youth study included 630 children, 8-10 years old at recruitment with at least one parent with overweight or obesity with 2-year follow-up.

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  • - The study examined how children transition between normal glucose tolerance and dysglycemia, particularly focusing on factors affecting this change from childhood to late adolescence in a sample of White Canadian children with obesity in their families.
  • - It found that 21% of children who had normal glucose levels initially developed dysglycemia, while a significant proportion (up to 75%) of those with dysglycemia reverted to normal glucose tolerance during puberty.
  • - Key predictors for developing dysglycemia were higher fasting and 2-hour glucose levels, with no significant demographic or lifestyle factors linked to increased risk, while beta-cell function notably decreased in children with excess weight.
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We evaluated the effect on long term blood pressure (BP) of an interprofessional team-based care (TBC) intervention, involving nurses, pharmacists, and physicians, compared to usual care. We conducted a pragmatic randomized controlled study in ambulatory clinics and community pharmacies in Switzerland (ClinicalTrials.gov: NCT02511093).

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Objectives: To confirm that World Health Organization weight-for-length z scores (zWFL) and World Health Organization body mass index z scores (zBMI) in infancy are associated with adiposity and cardiometabolic measures at 8-10 years old and to compare the predictive ability of the 2 methods.

Study Design: zWFL and zBMI at 6, 12, and 18 months of age were computed using data extracted from health booklets, among participants in the Québec Adipose and Lifestyle InvesTigation in Youth prospective cohort (n = 464). Outcome measures at 8-10 years included adiposity, lipid profile, blood pressure, and insulin dynamics.

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Purpose: The association between placental detachment disorders and risk of chronic disease is unclear. We determined the association of placenta accreta and retained placenta with risk of future maternal cardiovascular disease and cancer.

Methods: We tracked a longitudinal cohort of 541,051 pregnant women over a period of 13 years (2006-2019) in Quebec, Canada.

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Physicians, pharmacists and caregivers, as well as public health officials and citizens, must sort through the enormous amount of information circulating about the pandemic. This crisis is accompanied by a real « infodemic » via multiple media, digital and otherwise. Is circulating a mixture of reliable information but also of misinformation, fed by the obscurantism jeopardizing the implementation of interventions such as vaccination or mask-wearing.

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Background: Cannabis use is increasing in women of reproductive age, but whether cannabis use disorders increase the long-term risk of cardiovascular disease in this population is not known. Cannabis may cause tachycardia, hypertension, cerebral vasoconstriction, and other adverse cardiovascular effects and has been associated with acute myocardial infarction and stroke. Data on the long-term effects of cannabis on the cardiovascular system are more limited.

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