Publications by authors named "Gilles N Chironi"
Objectives: To test associations of circulating microparticles with large artery remodeling before atherosclerosis is detectable.
Methods: In 232 untreated symptom-free individuals, we measured microparticles of various cellular origins (platelet, endothelial and leukocyte) by specific anti-GPIb (glycoprotein Ib), anti-cluster of differentiation (CD) 105 and anti-CD11a antibodies, and common carotid artery intima-media thickness (IMT), internal and external diameters by ultrasound.
Results: Except for CD105 microparticles with IMT to lumen ratio (IMT/D, P < 0.
Purpose: Early artery wall-thickening detected by ultrasound-assessed increased carotid intima-media thickness (IMT) may reflect atherosclerosis or represent an adaptive response to keep homeostasis tensile stress that is related inversely to wall thickness by Laplace's equation. We attempted to discriminate between both mechanisms by correcting IMT for its inverse association with tensile stress.
Methods: Common carotid IMT and lumen diameter (D) where determined in 40 healthy controls and 119 never-treated asymptomatic patients with >or=1 traditional cardiovascular risk factor.
Article Synopsis
- * Endothelial microparticles (EMP) serve as indicators of endothelial dysfunction and are involved in processes like inflammation and thrombosis, with their levels increasing in various medical conditions related to endothelial injury.
- * Recent research highlights EMP's role in impairing blood vessel function and contributing to diseases such as acute coronary syndromes and multiple sclerosis, suggesting that understanding EMP could lead to new treatments for related conditions like atherothrombosis.