Synthesis, crystal structure, characterisation, and antifungal activity of 3-thiophene aldehyde semicarbazone (3STCH), 2,3-thiophene dicarboxaldehyde bis(semicarbazone) (2,3BSTCH2) and their nickel (II) complexes.

The reaction of nickel (II) chloride and bromide with 3-thiophene aldehyde semicarbazone (3STCH) and 2,3-thiophene dicarboxaldehyde bis(semicarbazone) (2,3BSTCH(2)) leads to the formation of a series of new complexes: [NiCl(2)(3STCH)(2)], [NiBr(2)(3STCH)(2)], [NiCl(2,3BSTCH(2))(H(2)O)]Cl, and [NiBr(2,3BSTCH(2))(H(2)O)]Br respectively. The crystal structures of the two ligands 3STCH, 2,3BSTCH(2) and of the complex [NiBr(2,3BSTCH(2))(H(2)O)]Br have been determined by X-ray diffraction methods. For all these complexes, the central ion is coordinated through the oxygen atom of the carbonyle and the azomethine nitrogen atom of the semicarbazone.

2,4-Dichloro-6-({2-[(3,5-dichloro-2-hy-droxy-benzyl-idene)amino]-eth-yl}imino-meth-yl)phenol.

The title mol-ecule, C(16)H(12)Cl(4)N(2)O(2), lies about an inversion center. The symmetry-unique part of the mol-ecule contains an intra-molecular O-H⋯N hydrogen bond. In the crystal, mol-ecules are arranged in corrugated layers parallel to (-101).

2-[N-(4-{4-[(2-Hy-droxy-5-meth-oxy-benzyl-idene)amino]-benz-yl}phen-yl)carboximido-yl]-4-meth-oxy-phenol.

In the title Schiff base, C(29)H(26)N(2)O(4), the complete molecule is generated by a crystallographic twofold axis and is V-shaped. The planes of the benzene rings of the central diphenyl-methane unit make a dihedral angle of 78.11 (4)° while adjacent benzene and 5-meth-oxy-salicyl-idene rings are twisted with respect to each other by a dihedral angle of 11.

Synthesis, crystal structure, characterization of zinc(II), cadmium(II) complexes with 3-thiophene aldehyde thiosemicarbazone (3TTSCH). Biological activities of 3TTSCH and its complexes.

The reaction of zinc(II) chloride, cadmium(II) chloride and bromide with 3-thiophene aldehyde thiosemicarbazone leads to the formation of a series of new complexes. They have been characterized by spectroscopic studies: infrared, (1)H NMR, and electronic spectra. The crystal structures of the compound [ZnCl(2)(3TTSCH)(2)] and [CdBr(2)(3TTSCH)(2)] have been determined by X-ray diffraction methods.

Bis(3-acetyl-6-methyl-2-oxo-2H-pyran-4-olato)bis-(dimethyl sulfoxide)nickel(II).

In the title compound, [Ni(C(8)H(7)O(4))(2){(CH(3))(2)SO}(2)], the Ni(II) atom is located on a crystallographic centre of symmetry and has a distorted octa-hedral coordination geometry of type MO(6). The bidentate dehydro-acetic acid (DHA) ligands occupy the equatorial plane of the complex in a trans configuration, and the dimethyl sulfoxide (DMSO) ligands are weakly coordinated through their O atoms in the axial positions.

A comparison of the acidity and the complexing ability of (o-hydroxyphenyl) bis- and (o-hydroxyphenyl) mono-methylenephosphonic acids towards lanthanide(III) ions.

The characterization of the acid-base properties of a family of three phenoldimethylenephosphonic acids differently substituted by auxo- or chromophoric groups was studied. These ligands may be considered as pentaacids. Their pK(a) were determined in aqueous solution at 25 degrees C and constant ionic strength 0.

Zwitterionic 6-methyl-2-oxo-3-[1-(ureido-iminio)eth-yl]-2H-pyran-4-olate monohydrate.

The title compound, C(9)H(11)N(3)O(4)·H(2)O, was prepared by the reaction of dehydro-acetic acid and semicarbazide hydro-chloride. It crystallizes in a zwitterionic form with cationic iminium and anionic enolate groups. In the crystal structure, the almost planar mol-ecules are held together by N-H⋯O, O-H⋯O and C-H⋯O hydrogen bonds, some of them involving the water molecules.

Synthesis, characterization and antifungal activity of a series of manganese(II) and copper(II) complexes with ligands derived from reduced N,N'-O-phenylenebis(salicylideneimine).

A series of manganese(II) and copper(II) complexes with reduced Schiff bases derived from o-phenylenediamine has been prepared and characterized by elemental analysis, TG measurements, ESR, magnetic measurements, FTIR, UV-Visible spectra and conductivity. These complexes were found to be [MnL(H2O)n] and [CuL](H2O)n species with n=0-2. Their antifungal activity was evaluated on different human fungi including yeasts of the Candida genus (C.

In vitro and in vivo effects of [Ni(M5FTSC)2Cl2] complex in cancer: preliminary tests.

The human colon adenocarcinoma-derived cell line CaCo-2 male Swiss mice and male Sprague-Dawley rats were used as model systems to study the effects of nickel (II), 5-methyl-2-furaldehyde thiosemicarbazone ligand and their complex. The stimulation effect of the complex was obtained with low concentrations from 3.7 x 10(-7) to 3.

Solvent effects on the stability of nifuroxazide complexes with cobalt(II), nickel(II) and copper(II) in alcohols.

A spectrophotometric study of the complexation of nifuroxazide with cobalt(II), nickel(II) and copper(II) was carried out in different alcohols. The formation of a complex in each case is reported and their stability constants have been calculated. For a given solvent, the stability of the complexes increases from cobalt to copper.