Exposure to School Racial Segregation and Late-Life Cognitive Outcomes.

Importance: Disparities in cognition, including dementia occurrence, persist between non-Hispanic Black (hereinafter, Black) and non-Hispanic White (hereinafter, White) older adults, and are possibly influenced by early educational differences stemming from structural racism. However, the association between school racial segregation and later-life cognition remains underexplored.

Objective: To investigate the association between childhood contextual exposure to school racial segregation and cognitive outcomes in later life.

Neighborhood Disadvantage in a Nationally Representative Sample of Community-Living Older US Adults.

Importance: Although neighborhood socioeconomic disadvantage has become the standard for evaluating contextual socioeconomic deprivation at the Census-block level, little is known about its prevalence or association with long-term mortality in nationally representative samples of older persons.

Objectives: To estimate the prevalence of neighborhood disadvantage among a nationally representative sample of community-living older adults; to identify how prevalence estimates differ based on relevant demographic, socioeconomic, geographic, clinical, and geriatric characteristics; and to evaluate the association between neighborhood disadvantage and all-cause mortality.

Design, Setting, And Participants: This cohort study analyzed linked data of community-living persons aged 65 years or older in the contiguous US participating in the National Health and Aging Trends Study (NHATS) from 2011 to 2021.

Insomnia Severity and Daytime Sleepiness in Caregivers of Advanced Age.

Objective: Aging-related changes and caregiver burden may increase the risk for sleep disturbances among older caregivers, yet few studies have examined the prevalence of insomnia and daytime sleepiness in this group. We examined the relationship of caregiver status with insomnia and daytime sleepiness among persons of advanced age (>75 years of age).

Design: Cross-sectional.

Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults.

Background And Objectives: Mounting evidence points to a strong connection between cardiovascular risk during middle age and brain health later in life. The American Heart Association's Life's Essential 8 (LE8) constitutes a research and public health construct capturing key determinants of cardiovascular health. However, the overall effect of the LE8 on global, clinically relevant metrics of brain health is still unknown.

Association Between Restricting Symptoms and Disability After Critical Illness Among Older Adults.

Objectives: Older adults who survive critical illness are at risk for increased disability, limiting their independence and quality of life. We sought to evaluate whether the occurrence of symptoms that restrict activity, that is, restricting symptoms, is associated with increased disability following an ICU hospitalization.

Design: Prospective longitudinal study of community-living adults 70 years old or older who were interviewed monthly between 1998 and 2018.

Population-based estimates of major forms of housing insecurity among community-living older Americans.

Objectives: The number of older adults struggling to maintain adequate housing is growing. Prior studies have used various criteria to measure housing insecurity; however, no standardized definition exists to date. Using a multidimensional approach, our study sought to calculate population-based estimates of various forms of housing insecurity among community-living older Americans and determine how these estimates differ across key characteristics.

Changes in neighborhood disadvantage over the course of 22 years among community-living older persons.

Background: Among older persons, neighborhood disadvantage is a granular and increasingly used social determinant of health and functional well-being. The frequency of transitions into or out of a disadvantaged neighborhood over time is not known. These transitions may occur when a person moves from one location to another or when the Neighborhood Atlas, the data source for the area deprivation index (ADI) that is used to identify disadvantaged neighborhoods at the census-block level, is updated.

Spatiotemporal analysis of sand and dust emission point sources detected from satellite imagery in Syria, Jordan, and Iraq.

This study utilized MODIS true color satellite imagery to analyse blowing sand and dust events dynamics in the Middle East from 2010 to 2021, focusing on Syria, Iraq, and Jordan. A total of 4923 dust point sources were detected, with a significant concentration (~90 %) located within the Tigris-Euphrates Basin (Nearest Neighbor Ratio = 0.41, р < 0.

Bidirectional relationship between epigenetic age and brain health events.

Chronological age offers an imperfect estimate of the molecular changes that occur with aging. Epigenetic age, which is derived from DNA methylation data, provides a more nuanced representation of aging-related biological processes. This study examines the bidirectional relationship between epigenetic age and the occurrence of brain health events (stroke, dementia, and late-life depression).

In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization.

Importance: Older adults who are hospitalized for COVID-19 are at risk of delirium. Little is known about the association of in-hospital delirium with functional and cognitive outcomes among older adults who have survived a COVID-19 hospitalization.

Objective: To evaluate the association of delirium with functional disability and cognitive impairment over the 6 months after discharge among older adults hospitalized with COVID-19.

Association of Childhood Exposure to School Racial Segregation with Late-Life Cognitive Outcomes among Older Americans.

Importance: Disparities in cognition, including dementia occurrence, persist between White and Black older adults, and are possibly influenced by early educational differences stemming from structural racism. However, the relationship between school racial segregation and later-life cognition remains underexplored.

Objective: To investigate the association between childhood contextual exposure to school racial segregation and cognitive outcomes in later life.

APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study.

Background: Clinical trials in older adults are increasingly focused on functional outcomes, and the composite outcome of dementia, disability, and death is gaining pivotal importance. Genetic variation, particularly the APOE epsilon(ε) variants, may modify responses to new treatments. Although APOE ε4 is known to influence these outcomes separately, the magnitude of its effect on this composite outcome remains unknown.

Association Between Cognitive Trajectories and Subsequent Health Status, Depressive Symptoms, and Mortality Among Older Adults in the United States: Findings From a Nationally Representative Study.

Background: Cognitive decline may be an early indicator of major health issues in older adults, though research using population-based data is lacking. Researchers objective was to assess the relationships between distinct cognitive trajectories and subsequent health outcomes, including health status, depressive symptoms, and mortality, using a nationally representative cohort.

Methods: Data were drawn from the National Health and Aging Trends Study.

Primary stability and osseointegration comparing a novel tapered design tissue-level implant with a parallel design tissue-level implant. An experimental in vivo study.

Objectives: The aim of the present study was to compare a novel tapered, double-threaded self-tapping tissue-Level design implant (TLC) to a well-established parallel walled tissue-level (TL) implant in terms of primary and secondary stability over time.

Materials And Methods: Test TLC (n = 10/per timepoint) and control TL (n = 10/per timepoint) implants were placed in the mandible of minipigs and left for submerged healing for 3, 6, and 12 weeks. Maximum insertion torque and implant stability quotient (ISQ) were measured for each implant at placement.

Early-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US.

Importance: Given the critical role of neurocognitive development in early life, understanding the association between early-life circumstances and racial disparities in cognition has important implications.

Objective: To assess whether racial differences in early-life circumstances are collectively and individually associated with racial disparities in late-life cognition among older adults in the US.

Design, Setting, And Participants: This cross-sectional study used comprehensive life history data from the Health and Retirement Study, a nationally representative survey of US adults 50 years or older.

Magnetic structure and properties of the honeycomb antiferromagnet [Na(OH)]Mn(NCS).

We report the magnetic structure and properties of a thiocyanate-based honeycomb magnet [Na(OH)]Mn(NCS) which crystallises in the unusual low-symmetry trigonal space group 3̄. Magnetic measurements on powder samples show this material is an antiferromagnet (ordering temperature = 18.1(6) K) and can be described by nearest neighbour antiferromagnetic interactions = -11.

Assessing readiness to use electronic health record data for outcome ascertainment in clinical trials - A case study.

Background: Variable data quality poses a challenge to using electronic health record (EHR) data to ascertain acute clinical outcomes in multi-site clinical trials. Differing EHR platforms and data comprehensiveness across clinical trial sites, especially if patients received care outside of the clinical site's network, can also affect validity of results. Overcoming these challenges requires a structured approach.

Identifying barriers and facilitators for using a smartwatch to monitor health among older adults.

Smartwatches are a type of wearable device that enable continuous monitoring of an individual's activities and critical health metrics. As the number of older adults age 65+ continues to grow in the U.S.

Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization.

Importance: Older adults with socioeconomic disadvantage develop a greater burden of disability after critical illness than those without socioeconomic disadvantage. The delivery of in-hospital rehabilitation that can mitigate functional decline may be influenced by social determinants of health (SDOH). Whether rehabilitation delivery differs by SDOH during critical illness hospitalization is not known.

2D Time-Domain Spectroscopy for Determination of Energy and Momentum Relaxation Rates of Hydrogen-Like Donor States in Germanium.

We present measurements of the coherence times of excited states of hydrogen-like arsenic impurities in germanium (Ge:As) using a table-top two-dimensional time-domain spectroscopy (2D-TDS) system. We show that this laboratory system is capable of resolving the coherence lifetimes of atomic-like excited levels of impurity centers in semiconductors, such as those used in solid-state quantum information technologies, on a subpicosecond time scale. By fitting the coherent nonlinear response of the system with the known intracenter transition frequencies, we are able to monitor coherent population transfer and decay of the transitions from the 2p and 2p states for different low excitation pulse fields.