Publications by authors named "Gili Yovel"
Monocyte-derived macrophages are essential for recovery after spinal cord injury, but their homing mechanism is poorly understood. Here, we show that although of common origin, the homing of proinflammatory (M1) and the "alternatively activated" anti-inflammatory (M2) macrophages to traumatized spinal cord (SC) was distinctly regulated, neither being through breached blood-brain barrier. The M1 macrophages (Ly6c(hi)CX3CR1(lo)) derived from monocytes homed in a CCL2 chemokine-dependent manner through the adjacent SC leptomeninges.
View Article and Find Full Text PDFNeural crest development involves epithelial-mesenchymal transition (EMT), during which epithelial cells are converted into individual migratory cells. Notably, the same signaling pathways regulate EMT function during both development and tumor metastasis. p53 plays multiple roles in the prevention of tumor development; however, its precise roles during embryogenesis are less clear.
View Article and Find Full Text PDFArticle Synopsis
- Macrophages are important for healing wounds, but scientists are trying to figure out how they help the recovery from spinal cord injuries, and there’s some confusion about their roles.
- In an experiment with injured mice, researchers looked at two types of macrophages: the ones already in the brain (microglia) and the new ones that come from the blood (monocyte-derived MPhi).
- They found that the new monocyte-derived MPhi help with recovery, and if they were removed, the mice had a harder time healing. When they added back the healthy monocytes, the mice were able to move better again.