Publications by authors named "Gili S"

The impact of anti-Spike monoclonal antibody (mAbs) treatment on the immune response of COVID19-patients is poorly explored. In particular, a comparison of the immunological influence of different therapeutic regimens has not yet been performed. Aim of the study was to compare the kinetic of innate and adaptive immune response as well as the SARS-CoV-2 specific humoral and T cell response in two groups of SARS-CoV-2-infected patients treated with two different mAbs regimens: Bamlanivimab/Etesevimab (BAM/ETE) or Casirivimab/Imdevimab (CAS/IMD).

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Background The detection of in-stent restenosis (ISR) with coronary CT angiography (CCTA) is challenging, but CT perfusion (CTP) has demonstrated improved diagnostic accuracy over CCTA in patients with stents. However, there are limited data on the performance of dynamic CTP, which allows noninvasive adjudication of regional myocardial blood flow. Purpose To compare the diagnostic performance of regadenoson-stress dynamic CTP with that of CCTA, using fractional flow reserve (FFR) and the index of microvascular resistance (IMR) as reference standards for epicardial coronary circulation and coronary microcirculation, respectively.

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  • This study evaluated semen quality variations among men seeking fertility evaluation across 12 regions in Spain, analyzing samples from 2,336 participants.
  • Significant differences in semen volume, sperm concentration, motility, and total motile sperm count were found, particularly highlighting Asturias as having the highest values compared to other locations.
  • The findings suggest that the observed variations in semen quality are consistent across the regions and unlikely due to inconsistencies in laboratory testing methods.
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Background And Objectives: The risk profiles, procedural characteristics, and clinical outcomes for women undergoing bifurcation percutaneous coronary intervention (PCI) are not well defined compared to those in men.

Methods: COronary BIfurcation Stenting III (COBIS III) is a multicenter, real-world registry of 2,648 patients with bifurcation lesions treated with second-generation drug-eluting stents. We compared the angiographic and procedural characteristics and clinical outcomes based on sex.

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  • The study investigates the significance of cardiac troponin (cTn) levels in predicting mortality in patients with Takotsubo syndrome (TTS), analyzing data from the International Takotsubo Registry.
  • It identifies that a cTn increase greater than 28.8 times the upper reference limit signals clinically relevant myocardial injury, correlating with a higher risk of mortality over 5 years (adjusted HR 1.58).
  • The findings enhance understanding of patient risk profiles in TTS, emphasizing the need for increased monitoring and follow-up for those with significant troponin elevations.
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Maintaining extracellular potassium (K) within narrow limits, critical for membrane potential and excitability, is accomplished through the internal redistribution of K between extracellular fluid (ECF) and intracellular fluid (ICF) in concert with the regulation of renal K output to balance K intake. Here we present evidence from high-precision analyses of stable K isotopes in rats maintained on a control diet that the tissues and organs involved in the internal redistribution of K differ in their speed of K exchange with ECF and can be grouped into those that exchange K with ECF either rapidly or more slowly ("fast" and "slow" pools). After 10 days of K restriction, a compartmental analysis indicates that the sizes of the ICF K pools decreased but that this decrease in ICF K pools was not homogeneous, rather occurring only in the slow pool (15% decrease, < 0.

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  • The study investigated changes in demographics, risk factors, clinical presentations, and outcomes of takotsubo syndrome (TTS) patients from 2004 to 2021, using data from the InterTAK registry.
  • Over the years, the proportion of male patients increased, and there was a rise in cases of midventricular TTS as well as significant growth in the incidence of physical triggers.
  • There was also a notable increase in 60-day mortality rates, although no significant change in 1-year mortality when excluding early deaths was observed, indicating a complex evolution of TTS and its management in recent years.
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Patent foramen ovale (PFO) is often diagnosed in patients with cryptogenic stroke, aged > 60-65 years, but few data report the outcomes of PFO closure in elderly patients. Consecutive patients undergoing PFO closure at a single institution between January 2006 and December 2011 were included. Baseline clinical features and cerebral imaging data were collected, and a RoPE score was calculated for each patient.

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Background: Surgical management of large ventral hernias (VH) has remained a challenge. Various techniques like anterior component separation and posterior component separation (PCS) with transversus abdominis release (TAR) have been employed. Despite the initial success, the long-term efficacy of TAR is not yet comprehensively studied.

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Antarctica, protected by its strong polar vortex and sheer distance from anthropogenic activity, was always thought of as pristine. However, as more data on the occurrence of persistent organic pollutants on Antarctica emerge, the question arises of how fast the long-range atmospheric transport takes place. Therefore, polycyclic aromatic hydrocarbons (PAHs) and oxygenated (oxy-)PAHs were sampled from the atmosphere and measured during 4 austral summers from 2017 to 2021 at the Princess Elisabeth station in East Antarctica.

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  • Small extracellular vesicles (sEVs) play a role in inflammation and vascular injury and may serve as potential diagnostic markers for diseases, particularly in STEMI patients.
  • A study analyzed plasma sEVs from 42 STEMI patients treated with primary percutaneous coronary intervention, revealing that sEV size and specific markers were linked to myocardial damage assessed by Cardiac Magnetic Resonance (CMR).
  • The results suggest that sEV size and the expression of CD41-CD61 could help identify patients at high risk for complications after a heart attack, leading to better treatment strategies.
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Background: Although Medina 0.0.1 bifurcation lesions are often treated by percutaneous coronary intervention (PCI) in real-world practice, the optimal revascularization strategy for this lesion is uncertain.

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  • Researchers developed a machine learning model to predict in-hospital death risk in Takotsubo syndrome (TTS) patients using data from over 3,400 individuals.
  • The model included 31 clinical variables and achieved strong performance results, with AUC values indicating high accuracy in identifying patients at risk of death.
  • Clustering analysis revealed six distinct patient groups with varying in-hospital death rates, demonstrating the model's ability to stratify risk profiles effectively.
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Background: Percutaneous closure represents the first line of treatment in patients with cryptogenic stroke and documented patent foramen ovale (PFO). Scarce data report the long-term outcomes of patients undergoing PFO closure with the Figulla Flex II device (Occlutech, Germany).

Methods: Consecutive patients undergoing PFO closure with a Figulla Flex II device at a single, high-volume Institution were included.

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Background: The ADVANTAGE study demonstrated in a cohort of stented patients a diagnostic accuracy of stress myocardial CT perfusion (CTP) significantly higher than that of coronary CT angiography (CCTA) for the detection of in-stent restenosis (ISR) or CAD progression vs. quantitative coronary angiography (QCA). This is a pre-defined subanalysis of the ADVANTAGE aimed at assessing the difference in terms of diagnostic accuracy vs.

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Background: Transradial approach for carotid artery stenting (TRCAS) is an established technique in specific anatomies potentially associated with high periprocedural event rate from femoral catheterization. The engagement of left common carotid artery originating from the aortic arch is the most challenging scenario requiring specific catheters and techniques.

Methods: Among 542 consecutive TRCAS 66 had left, non-bovine carotid stenosis as the target vessel.

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Antarctic ice cores have revealed the interplay between dust and climate in the Southern Hemisphere. Yet, so far, no continuous record of dust provenance has been established through the last deglaciation. Here, using a new database of 207 Rare Earth Element (REE) patterns measured in dust and sediments/soils from well-known potential source areas (PSA) of the Southern Hemisphere, we developed a statistical model combining those inputs to provide the best fit to the REE patterns measured in EPICA Dronning Maud Land (EDML) ice core (E.

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Hepatitis E virus (HEV) is an RNA virus responsible for over 20 million infections annually. HEV's open reading frame (ORF)1 polyprotein is essential for genome replication, though it is unknown how the different subdomains function within a structural context. Our data show that ORF1 operates as a multifunctional protein, which is not subject to proteolytic processing.

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  • This study looked at a method called transradial/brachial carotid artery stenting to help treat patients with blocked arteries in their necks.
  • The researchers treated 137 patients, most of whom were older men, and found that the procedure was mostly successful, with very few complications.
  • Only a small number of patients had strokes or complications, which means the method is considered safe and effective for high-risk patients.
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Background: Bifurcation percutaneous coronary intervention (PCI) is associated with higher risk of clinical events.

Objectives: This study aimed to determine clinical and lesion features that predict adverse outcomes, and to evaluate the differential prognostic impact of these features in patients undergoing PCI for bifurcation lesions.

Methods: We analyzed 5,537 patients from the BIFURCAT (comBined Insights From the Unified RAIN and COBIS bifurcAtion regisTries) registry.

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  • The study assessed in-hospital outcomes for nonagenarians (patients aged 90 and older) who underwent primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI) between 2009-2019.
  • Out of 308 patients, 32% experienced in-hospital death, with identified predictors including lower left ventricle ejection fraction (LVEF), lower systolic blood pressure (SBP), and lack of independence in daily activities.
  • The findings suggest that nonagenarian STEMI patients have a high mortality rate after pPCI, and maintaining independence in daily life is crucial for improving their chances of survival during hospitalization.
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As the most abundant cation in archaeal, bacterial, and eukaryotic cells, potassium (K) is an essential element for life. While much is known about the machinery of transcellular and paracellular K transport-channels, pumps, co-transporters, and tight-junction proteins-many quantitative aspects of K homeostasis in biological systems remain poorly constrained. Here we present measurements of the stable isotope ratios of potassium (K/K) in three biological systems (algae, fish, and mammals).

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Background: An unprecedented global monkeypox outbreak started in May, 2022. No data are yet available about the dynamics of the immune response against monkeypox virus. The aim of this study was to describe kinetics of T-cell response, inflammatory profile, and pox-specific T-cell induction in patients with laboratory-confirmed monkeypox.

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