Publications by authors named "Gildasio Castello Almeida"
Article Synopsis
- Ocular toxoplasmosis (OT) is an eye condition caused by a parasite that leads to inflammation of the retina and choroid, affecting vision; genetic variations in cytokine genes may influence susceptibility to this disease.
- A study categorized Brazilian participants with positive toxoplasmosis serology into two groups based on the presence or absence of OT, along with a control group without infection, to examine specific gene polymorphisms' roles.
- Findings indicated that individuals with the C/C genotype of a particular gene variant were less likely to develop OT, suggesting that this genetic factor may offer protection against the condition in the studied population.
Purpose: To assess the efficiency of an index derived from multiple logistic regression analysis (MLRA) to measure differences in corneal tomography findings between subclinical keratoconus (KC) in 1 eye, corneal ectasia, and healthy corneas.
Setting: 2 private Brazilian ophthalmological centers.
Design: Multicenter case-control study.
Purpose: To identify inherited or acquired mutations in the and genes from the combined analysis of corneal and blood samples from patients with Keratoconus.
Methods: The casuistry was consisted of samples of peripheral blood and corneal epithelium from 35 unrelated patients with Keratoconus who were submitted to corneal crosslink treatment. Also, blood and corneal epithelium samples from 89 non-keratoconic patients were used to compose the control group.
Background: Until a few years ago, keratoconus was defined as a noninflammatory degenerative disease. However, recent studies have shown that the altered balance between inflammatory cytokines, proteases, and protease inhibitors, as well as free radicals and oxidants, have a crucial role in the pathogenesis of this disease. The aim of this study is to investigate whether interleukin 17 A G197A (rs2275913) and interleukin 17 F T7488C (rs763780) polymorphisms are associated with keratoconus in patients from a population of the northwestern region of the State of São Paulo, Brazil.
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