Gallbladder cancer in Chile: Pathologic characteristics of survival and prognostic factors: analysis of 1,366 cases.

Objectives: To explore gallbladder cancer (GBC), the second leading cause of cancer-related death in women in Chile.

Methods: Analysis of macroscopic and microscopic variables, morphometry, and survival in 1,366 patients with GBC.

Results: Patients comprised 1,138 women and 228 men; diagnoses included 213 (15.

[Association between cholesterolosis and gallbladder cancer].

Background: Cholesterolosis is frequently observed in cholecystectomies performed for lithiasis or chronic cholecystitis.

Aim: To determine the degree of association between cholesterolosis and gallbladder cancer.

Material And Methods: In a prospective study of gallbladder cancer, all gallbladders obtained during cholecystectomies were processed for pathological study, following a special protocol.

Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: a case-control study.

Background: Gallstones are considered the most important risk factor for gallbladder cancer.

Aim: To identify differences in the number, weight, volume, and density of gallstones associated with chronic cholecystitis (CC), gallbladder dysplasia (GD), and gallbladder cancer (GBC).

Methods: A total of 125 cases were selected, of which 93 had gallstones associated with GBC and 31 had gallstones associated with GD.

[Inactivation of CDKN2A gene (p16) in gallbladder carcinoma].

Background: The CDKN2A gene encodes a cyclin dependent kinase inhibitor, p16, which promotes cell cycle arrest. Methylation of the promoter region transcriptionally inactivates the gene.

Aim: To study the relationship between methylation status of the prometer region of p16 gene, the immunohistochemical expression of p16 and clinical and morphological features of gallbladder carcinoma.

[Subserous gallbladder carcinoma: expression of cadherine-catenine complex].

Background: Subserous gallbladder carcinoma is difficult to diagnose and treat. There are no tissue markers with prognostic value in this type of tumor.

Aim: To study the immunohistochemical expression of E-cadherin alpha and beta catenin in subserous gallbladder carcinoma.

[Morphological prognostic elements in gallbladder cancer].

Background: The exact survival rates and prognostic factors of gallbladder cancer are still incompletely known.

Aim: To report the actuarial survival of patients with gallbladder cancer.

Material And Methods: Six hundred thirty seven women, aged 59 years old as a mean and 108 men, aged 64 years old as a mean, with gallbladder cancer are reported.