Publications by authors named "Gilberto Kat Kit Leung"
Anticancer Res
November 2010
Article Synopsis
- Glioblastoma cells utilize ion excretion for shape changes and migration, and this study explores inhibiting this process.
- Researchers examined chloride channel (ClC) and metalloproteinase-2 (MMP-2) expressions in glioma cell lines and tested various inhibitors, including chlorotoxin and NPPB.
- ClC-3 and MMP-2 inhibition reduced invasion but was not completely effective, while the non-specific inhibitor NPPB fully blocked invasion, indicating a need for targeting multiple ClCs in future therapies.
