Publications by authors named "Gilbert Pecoraro"
Article Synopsis
- Fibrosis, caused by excessive scarring after injury, accounts for over 40% of disease-related deaths worldwide and leads to the destruction of organ structure by activated fibroblasts.
- The study reveals that direct contact with profibrotic macrophages, rather than proinflammatory ones, triggers fibroblast contractions, dependent on specific proteins (αvβ3 integrin and Piezo1).
- This contact elevates calcium levels in fibroblasts, activating transcription factors that drive fibroblast activation, suggesting that targeting the mechanisms of macrophage-fibroblast interaction could help develop antifibrosis treatments.
