Lung deposition and pharmacokinetics of cyclosporine after aerosolization in lung transplant patients.

Purpose: Aerosolized cyclosporine (aCsA) has proven to be an effective therapy for refractory acute and chronic rejection in lung transplant (LTx) patients. The objective of this study is to evaluate the lung deposition and systemic absorption of aCsA after aerosolized cyclosporine administration in LTx patients in the immediate postoperative period.

Method: Cyclosporine (CsA) was administered intravenously (1.