Identification of the TRPA1 cannabinoid-binding site.

Chronic pain accounts for nearly two-thirds of conditions eligible for medical cannabis licenses, yet the mechanisms underlying cannabis-induced analgesia remain poorly understood. The principal phytocannabinoids, the psychoactive Δ-tetrahydrocannabinol (THC) and non-psychoactive cannabidiol (CBD), exhibit comparable efficacy in pain management. Notably, THC functions as an agonist of cannabinoid receptor 1 (CB1), whereas CBD shows minimal activity on CB1 and CB2 receptors.

Tricyclic Spirolactones as Modular TRPV1 Synthetic Agonists.

TRPV1 is a prominent signal integrator of the pain system, known to be activated by vanilloids, a family of endogenous and exogenous pain-evoking molecules, through the vanilloid-binding site (VBS). The extensive preclinical profiling of small molecule inhibitors provides intriguing evidence that TRPV1 inhibition can be a useful therapeutic approach. However, the dissimilarity of chemical species that activate TRPV1 creates a major obstacle to understanding the molecular mechanism of pain induction, which is viewed as a pivotal trait of the somatosensory system.

Accurate determination of plasmonic fields in molecular junctions by current rectification at optical frequencies.

Current rectification, i.e., induction of dc current by oscillating electromagnetic fields, is demonstrated in molecular junctions at an optical frequency.

Measurement of electronic transport through 1G0 gold contacts under laser irradiation.

Metal quantum point contacts (MQPCs) with dimensions comparable to the de Broglie wavelength of conducting electrons reveal ballistic transport of electrons and quantized conductance in units of G(0) = 2e(2)/h. We measure the transport properties of 1G(0) Au contacts under laser irradiation. The observed enhancement of conductance appears to be wavelength-dependent, while thermal effects on conductance are determined to be negligible.

Detection of heating in current-carrying molecular junctions by Raman scattering.

As the scaling of electronic components continues, local heating will have an increasing influence on the stability and performance of nanoscale electronic devices. In particular, the low heat capacity of molecular junctions means that it will be essential to understand local heating and heat conduction in these junctions. Here we report a method for directly monitoring the effective temperature of current-carrying junctions with surface enhanced Raman spectroscopy (SERS) that involves measuring both the Stokes and anti-Stokes components of the Raman scattering.

Fabrication of very high aspect ratio metal nanowires by a self-propulsion mechanism.

A novel synthesis method of very high aspect ratio metal nanowires is described. The synthesis utilizes a nanoporous membrane as a template and self-electrophoresis as a directed force that continuously push formed nanowires out of the pores in a rate that is identical to the rate of their elongation. As a result, while the pores of membranes are only 6 microm long, the formed nanowires could be more than 100 microm long.