Publications by authors named "Gilad N Silberberg"
Objective: The aim of this study was to investigate whether a shared genetic susceptibility exists between individuals with rheumatoid arthritis (RA) and individuals with myocardial infarction (MI)-including major MI risk factors-and to quantify the degree of any such overlap.
Methods: Genome-wide association study (GWAS) data for individuals with RA were constructed from a sample of 26,637 Swedish patients with RA and controls without RA. For patients with MI, GWAS data were obtained from a previously published meta-analysis.
Article Synopsis
- - The study aimed to explore how genetic factors impact the ability of early rheumatoid arthritis (RA) patients to stick with methotrexate (MTX) treatment over time.
- - A genome-wide association study (GWAS) was conducted with 3,902 Swedish early-RA patients, but no significant genetic markers were identified that influenced treatment persistence at 1 or 3 years.
- - Although no strong genetic associations were found, the research suggested a moderate heritability for treatment persistence and indicated that those with a higher genetic risk for RA might have lower MTX treatment persistence.
Objectives: To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets.
Methods: We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and ~1 million controls from Northwestern Europe. We searched for causal genes outside the HLA-locus through effect on coding, mRNA expression in several tissues and/or levels of plasma proteins (SomaScan) and did network analysis (Qiagen).