Publications by authors named "Gil-Moreno A"
Objective: The prognostic relevance of hormonal biomarkers in endometrial cancer (EC) has been well-established. A refined three-tiered risk model for estrogen receptor (ER)/progesterone receptor (PR) expression was shown to improve prognostication. This has not been evaluated in relation to the molecular subgroups.
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- Endometrial cancer is the most common gynecological cancer in wealthier countries and its rates are rising, particularly among women under 40, largely due to rising obesity and an aging population.
- Early diagnosis is crucial, as survival rates vary significantly with the stage of the disease at diagnosis, making effective screening strategies vital to catch the cancer early and improve treatment options.
- The review focuses on identifying high-risk populations, evaluating current screening methods, and exploring new molecular screening techniques that are minimally invasive and cost-effective for wider implementation.
Background: There has been a rise in endometrial cancer (EC) incidence leading to increased mortality. To counter this trend, improving the stratification of post-surgery recurrence risk and anticipating disease relapse and treatment resistance is essential. Liquid biopsy analyses offer a promising tool for these clinical challenges, though the best strategy for applying them in EC must be defined.
View Article and Find Full Text PDFObjective: To determine the prevalence and the risk factors for anal high-grade intraepithelial neoplasia and anal cancer (HSIL+) in women with HIV (WWH), and to compare them to women without HIV with other risk factors.
Design: Prospective cohort study.
Methods: WWH and women without HIV with other risk factors were included.
Objective: The aim of this study was to compare surgical complexity, post-operative complications, and survival outcomes between patients with minimal residual disease (completeness of cytoreduction (CC) score) CC-1 at the time of primary debulking surgery and those with complete cytoreduction (CC-0) at the time of interval debulking surgery.
Methods: A retrospective multicenter study was conducted of patients with advanced ovarian cancer (International Federation of Gynecology and Obstetrics stage IIIC-IV) who underwent cytoreductive surgery achieving either minimal or no residual disease between January 2008 and December 2015. Patients underwent either primary or interval debulking surgery after receiving ≥3 cycles of neoadjuvant chemotherapy.
Purpose: Cervical cancer is a viral-associated tumor caused by the infection with the human papilloma virus. Cervical cancer is an immunogenic cancer that expresses viral antigens. Despite being immunogenic, cervical cancer does not fully respond to immune checkpoint inhibitors (ICI).
View Article and Find Full Text PDFObjective: We aimed to evaluate the performance of endometrial cancer (EC) molecular classification in predicting extrauterine disease after primary surgery alone and in combination with other clinical data available in preoperative setting.
Methods: Retrospective single-center observational study including patients with endometrial adenocarcinoma treated with primary surgery between December 1994 and May 2022. Molecular profiling was performed using immunohistochemistry of p53, MLH1, PMS2, MSH2 and MSH6; and KASP genotyping of the 6 most common mutations of POLE gene.
Article Synopsis
- A study was conducted to compare the effects of surgical aortic staging through paraaortic lymphadenectomy (PALND) and imaging (noPALND) on recurrence rates and survival in patients with locally advanced cervical cancer (LACC).
- After analyzing data from 1,092 patients, it was found that those who underwent PALND had a significantly higher recurrence rate (28.0%) compared to those staged by imaging (15.0%).
- Patients in the PALND group also experienced poorer overall, cancer-specific, and disease-free survival outcomes, suggesting that surgical staging may lead to worse prognosis in LACC patients.
Purpose: Molecular classification of endometrial cancer (EC) has become a promising information to tailor preoperatively the surgical treatment. We aimed to evaluate the rate of lymph node metastases (LNM) in patients with EC according to molecular profile.
Methods: A systematic review and meta-analysis were performed according to PRISMA guidelines by searching in two major electronic databases (PubMed and Scopus), including original articles reporting lymph node metastases according to the molecular classification of EC as categorized in the ESGO-ESMO-ESP guidelines.
Article Synopsis
- Researchers looked at two blood tests, procalcitonin and CRP, to see if they could help predict problems after surgery for advanced ovarian cancer.
- They studied 92 patients and found that higher levels of these markers were linked to a condition called anastomotic leakage, where the surgical connections in the bowel may fail.
- The best time to check these blood tests for accurate results was found to be day 1 for procalcitonin and day 3 for CRP after surgery.
Introduction: The knowledge of BRCA status offers a chance to evaluate the role of the intraperitoneal route in patients selected by biomolecular profiles after primary cytoreduction surgery in advanced ovarian cancer.
Materials And Methods: We performed a retrospective, multicenter study to assess oncological outcomes depending on adjuvant treatment (intraperitoneal [IP] vs intravenous [IV]) and BRCA status (BRCA1/2 mutated vs. BRCA wild type [WT]).
Objectives: To investigate the pattern of first recurrence of disease in patients with endometrial cancer according to molecular classification, and to assess the independent role of molecular profiling in each type of failure.
Methods: Retrospective single-center study including patients diagnosed with endometrial cancer stage I-IVB (International Federation of Gynecology and Obstetrics 2009) between December 1994 and May 2022, who underwent primary surgical treatment and had a complete molecular profile. First recurrence was classified as isolated or multiple, and as vaginal, pelvic, peritoneal, nodal, and distant according to its location.
Endometrial cancer (EC) patients with metastatic/recurrent disease have limited treatment options and poor survival outcomes. Recently, we discovered the FGFR2c splice isoform is associated with poor prognosis in EC patients. Here we report the establishment of 16 EC patient-derived xenografts (PDX)-derived organoids (PDXOs) with or without FGFR2c expression.
View Article and Find Full Text PDFObjectives: The microcystic, elongated and fragmented pattern of invasion can be associated with an underestimation of the depth of myometrial invasion by imaging techniques. We aimed to evaluate the influence of microcystic, elongated and fragmented pattern of invasion in the diagnostic performance of transvaginal ultrasound scan and magnetic resonance imaging for the prediction of the depth of myometrial invasion in low-grade endometrioid endometrial carcinomas.
Methods: Prospective and consecutive study including all low-grade (G1-G2) endometrioid endometrial carcinomas diagnosed between October 2013 and July 2018 in a tertiary hospital.
Objectives: The objective of our study was to describe the characteristics of patients with endometrial cancer diagnosed with a first recurrence involving the lung, and to describe the prognostic role of the molecular profile. We also aimed to describe the prognostic outcomes after local treatment of recurrence (resection of lung metastases or stereotactic body radiation therapy) in a group of patients with isolated lung recurrence.
Methods: This was a retrospective, single-center study between June 1995 and July 2021.
Introduction: Epithelial ovarian cancer (EOC) is primarily confined to the peritoneal cavity. When primary complete surgery is not possible, neoadjuvant chemotherapy (NACT) is provided; however, the peritoneum-plasma barrier hinders the drug effect. The intraperitoneal administration of chemotherapy could eliminate residual microscopic peritoneal tumor cells and increase this effect by hyperthermia.
View Article and Find Full Text PDFBackground: Sentinel lymph node (SLN) biopsy has recently been accepted to evaluate nodal status in endometrial cancer at early stage, which is key to tailoring adjuvant treatments. Our aim was to evaluate the national implementation of SLN biopsy in terms of accuracy to detect nodal disease in a clinical setting and oncologic outcomes according to the volume of nodal disease.
Patients And Methods: A total of 29 Spanish centers participated in this retrospective, multicenter registry including patients with endometrial adenocarcinoma at preoperative early stage who had undergone SLN biopsy between 2015 and 2021.
Background: Axillary management in cN + axillary nodes after neoadjuvant systemic therapy (NST) in breast cancer (BC) remains under research with the aim of de-escalation of axillary node dissection (ALND). Several axillary guided localization techniques have been reported. This study evaluates the safety of intraoperative ultrasound (IOUS) guided targeted axillary dissection (TAD) in a large sample after the results of ILINA trial.
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- Patients with high-grade endometrial carcinoma (EC) have a higher likelihood of tumor spread and lymph node metastasis (LNM), with preoperative imaging and CA125 levels aiding in their assessment.
- A study involving 333 high-grade EC patients found that elevated CA125 levels significantly correlated with advanced disease stages and poorer survival outcomes.
- Logistic regression analysis indicated that elevated CA125, non-endometrioid histology, deep myometrial invasion, and cervical involvement are strong predictors of LNM, while CT findings alone were less predictive.
Article Synopsis
- - The report investigates the use of radioguided occult lesions localization (ROLL) for surgically excising isolated relapses of gynecologic tumors, highlighting its technical aspects and complications.
- - Eight patients underwent ROLL procedures, successfully removing all targeted lesions without significant intraoperative complications; the average surgery lasted 120 minutes with minimal blood loss.
- - The findings suggest that ROLL surgery is a promising new approach for treating isolated recurrences in gynecological cancers, although one postoperative complication was noted.