Publications by authors named "Gijs Kerpershoek"
Article Synopsis
- The HPV16-SLP vaccine targeting oncoproteins E6 and E7 is being investigated for its safety and efficacy in treating advanced or recurrent HPV16-induced gynecological cancers, particularly cervical cancer.
- Preliminary results showed that the vaccine was well tolerated, with only mild flu-like symptoms reported and no severe systemic toxicity, while 9 out of 16 patients exhibited immune responses to the vaccine.
- However, despite these immune responses, the study found no tumor regression in the evaluable patients, and most experienced disease progression with a median survival of 12.6 months.
Pericardial fat accumulation has been associated with an increased cardiovascular risk. A very low calorie diet (VLCD) improves the cardiovascular risk profile in patients with type 2 diabetes mellitus (T2DM), by improving the metabolic profile, heart function, and triglyceride (TG) stores in (non)adipose tissues. However, long-term effects of a VLCD on pericardial fat volume and tissue-specific TG accumulation have not been documented.
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