Publications by authors named "Gigan M"
The aim of this study was to describe the outcomes of targeted COVID-19 treatments in immunocompromised patients with asymptomatic or mild COVID-19 during the period of expansion of the different Omicron subvariants in France. A retrospective monocentric observational study was performed. All immunocompromised patients aged 18 or more, with asymptomatic SARS-CoV-2 infection or mild COVID-19, and who had received a targeted treatment with sotrovimab, tixagevimab/cilgavimab, nirmatrelvir/ritonavir or remdesivir at the Bordeaux University Hospital from 1st January 2022 to 31st December 2022 were eligible.
View Article and Find Full Text PDFBackground: In older patients, multiple chronic conditions lead topolypharmacy which is associated with a higher risk of adverse drug events. Nowadays, the medication exposure of older patients with bleeding disorders has been poorly explored.
Aim: The aim of this study was to assess the prevalence of polypharmacy and the medication regimen complexity in older community-dwelling patients with hemophilia or von Willebrand Disease (VWD).
Article Synopsis
- The pharmacokinetics of immunosuppressants necessitate measuring blood concentrations for appropriate dosage adjustments, especially in renal transplant patients to prevent graft rejection.* -
- Therapeutic Drug Monitoring (TDM) is beneficial not only for transplant patients but also for autoimmune diseases like systemic lupus and lupus nephritis, despite limited data on its efficacy for certain drugs.* -
- Further studies are essential to establish TDM thresholds and conditions, while specific recommendations like TPMT phenotyping for azathioprine are advised before use.*
What Is Known And Objective: In older patients, multiple chronic conditions lead to the intake of multiple medications and a higher risk of adverse drug events. The exposure to inappropriate medications in older patients with bleeding disorders is poorly explored. The aim of this study was to describe the exposure to potentially inappropriate medications (PIMs) and medications with anticholinergic and sedative properties in older community-dwelling patients with haemophilia or von Willebrand Disease (VWD).
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