Pharma Collaboration for Transparent Medical Information (phactMI) Benchmark Study: Trends, Drivers, Success Factors, and Value of Globalization in Medical Information.

Background: Over the past decade, biopharmaceutical companies have been progressively establishing global frameworks across their capabilities. It is well recognized that the Medical Information (MI) department is a key externally facing function that needs to maintain a consistent focus on optimizing its capabilities of addressing product medical inquiries worldwide.

Methods: In the United States, a consortium named Pharma Collaboration for Transparent Medical Information, phactMI, a collaboration of pharmaceutical company MI departments dedicated to supporting health care professionals in their commitment to provide quality patient care, has provided a forum to benchmark and share best practices across the companies.

Measurement of Coherent π^{+} Production in Low Energy Neutrino-Carbon Scattering.

We report the first measurement of the flux-averaged cross section for charged current coherent π^{+} production on carbon for neutrino energies less than 1.5 GeV, and with a restriction on the final state phase space volume in the T2K near detector, ND280. Comparisons are made with predictions from the Rein-Sehgal coherent production model and the model by Alvarez-Ruso et al.

Measurement of Muon Antineutrino Oscillations with an Accelerator-Produced Off-Axis Beam.

T2K reports its first measurements of the parameters governing the disappearance of ν[over ¯]_{μ} in an off-axis beam due to flavor change induced by neutrino oscillations. The quasimonochromatic ν[over ¯]_{μ} beam, produced with a peak energy of 0.6 GeV at J-PARC, is observed at the far detector Super-Kamiokande, 295 km away, where the ν[over ¯]_{μ} survival probability is expected to be minimal.

Poisonings Associated with Intubation: US National Poison Data System Exposures 2000-2013.

Patients may be intubated after exposure to a variety of substances because of respiratory failure, CNS sedation, pulmonary pathology, or cardiovascular instability. However, there is little data describing the types of substances that are associated with endotracheal intubation or the rates of intubation after these exposures. Evaluation of this association may inform future research on intubation after exposures to specific substances and guide poison prevention education.

Measurement of the inclusive electron neutrino charged current cross section on carbon with the T2K near detector.

The T2K off-axis near detector ND280 is used to make the first differential cross-section measurements of electron neutrino charged current interactions at energies ∼1  GeV as a function of electron momentum, electron scattering angle, and four-momentum transfer of the interaction. The total flux-averaged ν(e) charged current cross section on carbon is measured to be ⟨σ⟩(ϕ)=1.11±0.

Review of the Evolution of Medical Information in Light of Changes in the External Landscape.

Over the past 25 years, biopharmaceutical companies have faced and adapted to an external landscape that has grown increasingly complex and challenging. Medical information departments have played a fundamental role in the globalization process through their development of multichannel customer-facing resources that address the complexities with innovative solutions. The authors conducted a survey to determine key components of the globalization of medical information departments in large biopharmaceutical companies.

Biopharmaceutical Contact Centers and Combination Products: Results of a Benchmark Survey.

Biopharmaceutical contact centers are expanding core skill sets when it comes to addressing inquiries regarding combination products. An inside look at how biopharmaceutical companies are handling this increasingly common scenario is provided through a benchmark survey, which was conducted between December 2012 and January 2013. The purpose of this survey was to collect and share contact center best practices on the handling of combination products in the biopharmaceutical industry.

Precise measurement of the neutrino mixing parameter θ23 from muon neutrino disappearance in an off-axis beam.

New data from the T2K neutrino oscillation experiment produce the most precise measurement of the neutrino mixing parameter θ23. Using an off-axis neutrino beam with a peak energy of 0.6 GeV and a data set corresponding to 6.

Observation of electron neutrino appearance in a muon neutrino beam.

The T2K experiment has observed electron neutrino appearance in a muon neutrino beam produced 295 km from the Super-Kamiokande detector with a peak energy of 0.6 GeV. A total of 28 electron neutrino events were detected with an energy distribution consistent with an appearance signal, corresponding to a significance of 7.

Measurement of neutrino oscillation parameters from muon neutrino disappearance with an off-axis beam.

The T2K Collaboration reports a precision measurement of muon neutrino disappearance with an off-axis neutrino beam with a peak energy of 0.6 GeV. Near detector measurements are used to constrain the neutrino flux and cross section parameters.

Indication of electron neutrino appearance from an accelerator-produced off-axis muon neutrino beam.

The T2K experiment observes indications of ν(μ) → ν(e) appearance in data accumulated with 1.43×10(20) protons on target. Six events pass all selection criteria at the far detector.

2009 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 27th Annual Report.

Background: This is the 27th Annual Report of the American Association of Poison Control Centers' (AAPCC) National Poison Data System (NPDS). As of 1 July 2009, 60 of the nation's 60 US poison centers (PCs) uploaded case data automatically. The upload time was 19.

2008 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 26th Annual Report.

Background: This is the 26th Annual Report of the American Association of Poison Control Centers (AAPCC; http://www. aapcc.org ) National Poison Data System (NPDS).

Budget cuts and U.S. Poison Centers - regional challenges create a nationwide problem.

Federal funding of poison centers (PCs) in the United States was established in 2000 through the Poison Control Center Enhancement and Awareness Act. Unfortunately, the problems with financial stability of PCs that this legislation was intended to improve persist because of continued reliance on fragile local funding sources. In the past few months budget cuts have had an impact on PC activity and threaten the continued existence of a nationwide network of PCs in the United States.

Thermal and optical properties of polymer hosts for solid-state dye lasers.

We present measurements of thermal and optical properties of poly(methyl methacrylate) (PMMA), PMMA modified by the addition of ethanol (MPMMA), and copolymers of methyl methacrylate with 2-hydroxyethyl methacrylate [P(HEMA:MMA)]. Spectral transmission of the polymers is excellent (alpha = 0.5 cm(-1) at 400 nm, decreasing to 0.

Case report: a metabolic disorder presenting as pediatric manganism.

Context: Manganese is a trace element, essential for physiologic functioning but neurotoxic at high doses. Common exposure sources include dietary intake as well as drinking water in some regions; toxicity is most often associated with inhalation exposures in occupational settings. In this article we describe the investigation of a pediatric case of manganism using both clinical and environmental assessment methods.

Tunable visible solid-state lasers based on second-harmonic generation of LiF:F(2) in potassium titanyl phosphate.

A new broadly tunable visible solid-state laser is reported. Wavelengths between 550 and 610 nm are generated by intracavity frequency doubling of tuned and free-running room-temperature pulsed LiF:F(2)(-) lasers in potassium titanyl phosphate. Second-harmonic energy of 1.

Tunable visible solid-state lasers based on intracavity frequency doubling of Cr:forsterite in KTP.

Broadband tunability in the yellow-red region is obtained by use of intracavity type II second-harmonic generation of gain-switched Cr:forsterite lasers in KTiOPO(4) . An operating wavelength range of 67 nm, from 587 to 654 nm, is obtained. Second-harmonic energy of almost 1 mJ is achieved at a peak wavelength of 620 nm.

Identical genotype B3 sequences from measles patients in 4 countries, 2005.

Surveillance of measles virus detected an epidemiologic link between a refugee from Kenya and a Dutch tourist in New Jersey, USA. Identical genotype B3 sequences from patients with contemporaneous cases in the United States, Canada, and Mexico in November and December 2005 indicate that Kenya was likely to have been the common source of virus.

Evaluation of the US Oncology Network's recommended guidelines for therapeutic substitution with darbepoetin alfa 200 microg every 2 weeks in both naïve patients and patients switched from epoetin alfa.

Study Objective: To evaluate the efficacy of darbepoetin alfa 200 microg subcutaneously every 2 weeks after therapeutic substitution for epoetin alfa.

Design: Retrospective multicenter chart review.

Setting: Three US Oncology-affiliated outpatient sites.

Regional variation in the incidence of symptomatic pesticide exposures: applications of geographic information systems.

Objective: To evaluate the epidemiology of symptomatic human pesticide exposures using poison control center data and geographic information systems.

Methods: All symptomatic human pesticide exposures reported to the poison center during the period from January 1 to December 31, 2000 were included for analysis using geographic information systems. A space-time scan statistic was utilized to evaluate for clustering of symptomatic human exposures.

Efficient 550-600-nm tunable laser based on noncritically phase-matched frequency doubling of room-temperature LiF:F2- in lithium triborate.

We report on efficient conversion of a 1064-nm Nd:YAG laser to tunable visible light. The conversion scheme uses noncritically phase-matched second-harmonic generation of a pulsed Nd:YAG-pumped LiF:F2- laser in lithium triborate. Optimization yields 42% LiF:F2- laser efficiency and 56% frequency-doubling efficiency, providing >20% conversion from 1064 nm to broadly tunable visible output.

Pesticide-related illness: are poison centers reporting to the state health department?

Pesticide-related illness should be reported by physicians to state health departments. Since poison centers (PC) are involved in the management of many of these cases, it may be assumed that they should report these cases. A 5-y audit of pesticide related illness reported to a centralized state pesticide oversight agency (PARC) was conducted.

Oregon's Toxic Household Products Law.

In 1991, Oregon became the first state in the U.S. to require the addition of an aversive agent to ethylene glycol-containing antifreeze and methanol-containing windshield wiper fluid.