Publications by authors named "Giesla Moehren"
Article Synopsis
- IGF-I is important for cell cycle progression and survival, but it shows minimal binding to hepatocytes, leaving its role in their signaling unclear.
- Des(1-3)IGF-I can activate IGF-IR phosphorylation despite IGF-I's inactivity, and confocal microscopy confirmed the presence of IGFBP-3 on the hepatocyte surface.
- EGF activates IGF-IR through a transactivation pathway involving Src kinases, demonstrating that EGF influences IGF-IR signaling and revealing a potential inhibitory effect of IGFBP-3 on IGF-I signaling in hepatocytes.
