Incidence of Glaucoma or Ocular Hypertension After Repeated Anti-Vascular Endothelial Growth Factor Injections for Macular Degeneration.

Purpose: To estimate the risk of glaucoma or sustained ocular hypertension (OHT) related to anti-vascular endothelial growth factor (VEGF) injections for age-related macular degeneration (AMD).

Design: Retrospective chart review.

Subjects: Patients who received unilateral anti-VEGF injections for AMD at the Wheaton Eye Clinic (IL).

Macular thickness mapping in exudative age-related macular degeneration.

Purpose: To report the feasibility of retinal thickness mapping for evaluating thickness differences in retinal areas with and without leakage shown by fluorescein angiography for patients who have age-related macular degeneration with choroidal neovascularization.

Methods: A custom-built version of the retinal thickness analyzer was used for thickness mapping. Retinal thickness was defined as the separation between vitreoretinal and pigment epithelium-choroid interfaces.

Localized retinal dysfunction in central serous chorioretinopathy as measured using the multifocal electroretinogram.

Purpose: To determine the extent of electrophysiologic dysfunction in patients with central serous chorioretinopathy (CSC).

Design: Prospective observational case series.

Participants: Six patients with unilateral CSC (mean age, 40 years) were recruited into the study.

Retinal topography and thickness mapping in atrophic age related macular degeneration.

Aim: To determine the relation between alterations in the retinal topography and thickness, visual acuity, and retinal pigment epithelium hypopigmentation in atrophic age related macular degeneration (AMD).

Methods: 22 patients, mean age 74 (SD 8) years, with atrophic AMD were recruited. An optical imaging system based on the retinal thickness analyser (RTA) was applied to generate a series of 20 optical section images that encompass 2 mm x 2 mm retinal areas.

Findings on retinal topography and thickness mapping in age-related macular degeneration.

Purpose: To report alterations in the retinal topography and thickness in typical cases of age-related macular degeneration (ARMD).

Methods: An optical imaging system was applied to patients with ARMD with alterations in the retinal structures. The system generates a series of 20 optical section images that encompass a 2 mm x 2 mm retinal area.

Aqueous and vitreous penetration of levofloxacin after oral administration.

Objective: To investigate the penetration of levofloxacin, an optical S-(-)isomer of ofloxacin, into the aqueous and vitreous humor after oral administration.

Design: Randomized, clinical trial comparing tissue levels of levofloxacin after one or two doses 12 hours apart.

Participants: Forty-five patients undergoing initial vitrectomy between February 1997 and June 1997 at the UIC Eye Center.

Outcome of vitreoretinal surgery and penetrating keratoplasty using temporary keratoprosthesis.

Purpose: The use of a temporary keratoprosthesis has allowed earlier surgical intervention in eyes with coexisting vitreoretinal and corneal disease. We analyzed our experience with this type of surgery.

Methods: We retrospectively reviewed charts of patients in whom a temporary keratoprosthesis was used between 1987 and 1998.

Intraocular penetration of gentamicin after once-daily aminoglycoside dosing.

Background: Intraocular concentrations-particularly intravitreal concentrations-after systemic administration of gentamicin are poor. Once-daily aminoglycoside dosing of intravenous gentamicin achieves peak serum levels up to five times higher than conventional dosing. Whether these increased serum levels of gentamicin improve the aqueous or vitreous concentrations in humans has not been determined.

Clinical assessment of the macula by retinal topography and thickness mapping.

Purpose: To report a quantitative and objective method for assessing pathologic alterations in retinal structures to improve the evaluation of macular diseases.

Methods: We used a system based on the scanning retinal thickness analyzer to generate serial optical section images of the retina and provide mapping of the retinal topography and thickness in a normal subject and in patients with representative maculopathies including traumatic macular hole, central serous chorioretinopathy, branch retinal vein occlusion, diabetic macular edema, and retinal pigment epithelial detachment.

Results: The effectiveness of the system in imaging both the vitreoretinal and chorioretinal interfaces was confirmed in the normal subject and in patients with various maculopathies.

Influence of the cannulated vitrectomy system on the occurrence of iatrogenic sclerotomy retinal tears.

Purpose: To determine whether the use of the cannulated vitrectomy system decreases the incidence of sclerotomy-related retinal tears relative to traditional vitrectomy techniques.

Methods: Forty-one eyes of 77 patients in this study were randomly selected to undergo treatment with the cannulated port system.

Results: We demonstrated a statistically significant decreased incidence of sclerotomy tears in the cannulated group relative to the noncannulated group (1% vs.

Knowledge or noise. Scientific publication and the electronic journal.

Over the last few years, the Internet has grown exponentially and is developing a role in the exchange of scientific information. However, a number of problematic issues are associated with electronic publications, including limited transmission speed, undependable file longevity, poorly documented postpublication editing, copyright infringement, and cultural impediments to acceptance. By measure of citation frequency, electronic journals seem to have limited influence within scientific discourse, but this medium is as yet in its infancy.

Aspartate separation of the scotopic threshold response (STR) from the photoreceptor a-wave of the cat and monkey ERG.

We recorded ERG responses at the cornea of cat and monkey and identified the initial negative wave elicited by very dim stimuli as the scotopic threshold response (STR) comparable to that previously recognized by intraretinal recordings of cat. The STR, but not the photoreceptor a-wave, was eliminated by intravitreal aspartate in both cat and monkey, which demonstrated that the STR origin was post-photoreceptoral. Intraretinal recordings before and after aspartate confirmed that the a-wave of cat with bright light was fast-PIII from photoreceptors, and further showed that there was minimal or no extracellular activity recordable near the photoreceptors with very dim stimuli after aspartate.