Recommended procedures for managing carious lesions in primary teeth with pulp involvement-a scoping review.

Background: Managing dental caries in primary teeth with pulp involvement is a significant challenge. Clinical guidelines offer recommendations for effective management.

Aim: To identify and analyze policies, guidelines, and recommendations for treating primary teeth with pulp-involved carious lesions, highlighting existing research gaps and setting the foundation for future research.

The interplay of post-translational protein modifications in Arabidopsis leaves during photosynthesis induction.

Diurnal dark to light transition causes profound physiological changes in plant metabolism. These changes require distinct modes of regulation as a unique feature of photosynthetic lifestyle. The activities of several key metabolic enzymes are regulated by light-dependent post-translational modifications (PTM) and have been studied at depth at the level of individual proteins.

The functionality of plant mechanoproteins (forisomes) is dependent on the dual role of conserved cysteine residues.

Forisomes are giant polyprotein complexes that undergo reversible conformational rearrangements from a spindle-like to a plug-like state in response to Ca or changes in pH. They act as valves in the plant vasculature, and reproduce this function in vitro to regulate flow in microfluidic capillaries controlled by electro-titration. Heterologous expression in yeast or plants allows the large-scale production of tailor-made artificial forisomes for technical applications.

Acetylation of conserved lysines fine-tunes mitochondrial malate dehydrogenase activity in land plants.

Plants need to rapidly and flexibly adjust their metabolism to changes of their immediate environment. Since this necessity results from the sessile lifestyle of land plants, key mechanisms for orchestrating central metabolic acclimation are likely to have evolved early. Here, we explore the role of lysine acetylation as a post-translational modification to directly modulate metabolic function.

Mass Spectrometry-Based Quantitative Cysteine Redox Proteome Profiling of Isolated Mitochondria Using Differential iodoTMT Labeling.

Mitochondria are central hubs of redox biochemistry in the cell. An important role of mitochondrial carbon metabolism is to oxidize respiratory substrates and to pass the electrons down the mitochondrial electron transport chain to reduce oxygen and to drive oxidative phosphorylation. During respiration, reactive oxygen species are produced as a side reaction, some of which in turn oxidize cysteine thiols in proteins.

Knowledge and Attitudes Toward Renal Transplantation in Individuals Undergoing Transplant Evaluation.

Introduction: The underutilization of kidney transplant as the preferred treatment for end-stage kidney disease is influenced by a lack of knowledge, poor attitudes, and various socio-demographic characteristics. Negative attitudes toward renal transplant disengage patients from the evaluation process and often hinder their likelihood of receiving a transplant.

Purpose: Determine whether a standardized educational session successfully improves knowledge and attitudes toward kidney transplant.

Modeling muscle regeneration in RNA toxicity mice.

RNA toxicity underlies the pathogenesis of disorders such as myotonic dystrophy type 1 (DM1). Muscular dystrophy is a key element of the pathology of DM1. The means by which RNA toxicity causes muscular dystrophy in DM1 is unclear.

Two mitochondrial phosphatases, PP2c63 and Sal2, are required for posttranslational regulation of the TCA cycle in Arabidopsis.

Protein phosphorylation is a well-established post-translational mechanism that regulates protein functions and metabolic pathways. It is known that several plant mitochondrial proteins are phosphorylated in a reversible manner. However, the identities of the protein kinases/phosphatases involved in this mechanism and their roles in the regulation of the tricarboxylic acid (TCA) cycle remain unclear.

High-Resolution Lysine Acetylome Profiling by Offline Fractionation and Immunoprecipitation.

Acetylation of lysine side chains at their ε-amino group is a reversible posttranslational modification (PTM), which can affect diverse protein functions. Lysine acetylation was first described on histones, and nowadays gains more and more attention due to its more general occurrence in proteomes, and its possible crosstalk with other protein modifications. Here we describe a workflow to investigate the acetylation of lysine-containing peptides on a large scale.

Compassion Fatigue and Satisfaction: Influence on Turnover Among Oncology Nurses at an Urban Cancer Center.

Background: Oncology nurses are exposed to stressors that may contribute to compassion fatigue (CF), leading to high rates of turnover, potential financial implications for organizations, and concerns for patient safety and employee well-being.

Objectives: The purpose of this study was to explore the relationship among CF, compassion satisfaction (CS), and turnover intention in a sample of 93 inpatient oncology nurses at a 90-bed urban cancer center.

Methods: Data were collected using paper surveys.

In vivo evidence for a regulatory role of phosphorylation of Rubisco activase at the Thr78 site.

Rubisco activase (Rca) is phosphorylated at threonine-78 (Thr78) in low light and in the dark, suggesting a potential regulatory role in photosynthesis, but this has not been directly tested. To do so, we transformed an -knockdown mutant largely lacking redox regulation with wild-type Rca-β or Rca-β with Thr78-to-Ala (T78A) or Thr78-to-Ser (T78S) site-directed mutations. Interestingly, the T78S mutant was hyperphosphorylated at the Ser78 site relative to Thr78 of the Rca-β wild-type control, as evidenced by immunoblotting with custom antibodies and quantitative mass spectrometry.

Interaction Between SH Guided Waves and Tilted Surface-Breaking Cracks in Plates.

The interaction between SH guided waves and simple defects is well understood and documented, and the SH and related torsional guided waves are commonly used in inspection. However, tilted and branching cracks, for which vertical notches are a poor approximation, are found in some environments, particularly when pipes are buried in alkaline soils. This paper studies the interaction between SH guided waves and tilted, surface-breaking cracks, investigating the effect of the tilt and depth of the defect.

Soft Tissue Injuries of the Finger and Thumb.

Soft tissue digital injury of the hand is a common presenting complaint in the emergency setting. Although initial work-up requires physical examination and radiographs, many of these entities may be radiographically occult and solely appreciated on ultrasound (US) or magnetic resonance imaging (MRI). If undiagnosed, these conditions may lead to sequela of untreated disease including early osteoarthritis, pain, permanent deformity, and immobility.

Evidence-based pediatric asthma interventions and outcome measures in a healthy homes program: An integrative review.

Objective: Asthma disproportionately impacts and has poorer outcomes in low-income, minority, and inner-city children. The home environment has a profound impact on a child's asthma. Home-based asthma visits have the potential to positively impact a child's asthma, especially in targeted populations.

Beyond Histones: New Substrate Proteins of Lysine Deacetylases in Arabidopsis Nuclei.

The reversible acetylation of lysine residues is catalyzed by the antagonistic action of lysine acetyltransferases and deacetylases, which can be considered as master regulators of their substrate proteins. Lysine deacetylases, historically referred to as histone deacetylases, have profound functions in regulating stress defenses and development in plants. Lysine acetylation of the N-terminal histone tails promotes gene transcription and decondensation of chromatin, rendering the DNA more accessible to the transcription machinery.

T-protein is present in large excess over the other proteins of the glycine cleavage system in leaves of Arabidopsis.

T-protein is present in large excess over the other proteins of the glycine cleavage system in leaves of Arabidopsis and therefore, exerts little control over the photorespiratory pathway. T-protein is the aminomethyltransferase of the glycine cleavage multienzyme system (GCS), also known as the glycine decarboxylase complex, and essential for photorespiration and one-carbon metabolism. Here, we studied what effects varying levels of the GCS T-protein would have on GCS activity, the operation of the photorespiratory pathway, photosynthesis, and plant growth.

Cost-Effectiveness of Health Coaching: An Integrative Review.

Purpose/objectives: The purpose of this review was to evaluate published literature to distinguish how health coaching influences the cost of chronic disease management in insured adults with chronic conditions.

Primary Practice Setting: An integrated literature review was conducted. MEDLINE, Business Source Complete, and OneSearch were searched for the years 2001-2016 utilizing the following key words: health coaching, health coaching AND insurance companies, health coaching AND cost, health coaching AND health insurance, and health coaching AND insurance cost.

Resonant grating polarizers made with silicon nitride, titanium dioxide, and silicon: design, fabrication, and characterization.

We present the design, fabrication, and characterization of guided-mode resonance (GMR) linear polarizers that operate in the optical communications C-band near a wavelength of 1550 nm. We provide theoretical and experimental spectra using resonant elements fashioned in three material systems. In particular, we investigate silicon nitride resonant gratings and titanium dioxide gratings on glass substrates as well as silicon-on-quartz gratings.

Guided-mode resonant coherent light absorbers.

We present a new class of coherent perfect absorbers based on guided-mode resonance in thin semiconductor films. Using particle-swarm optimization methods, we design a thin-film amorphous silicon grating that maximizes coherent modulation of the absorbance. The optimized device exhibits a maximum scattering power of ∼94% and a power absorption limit approaching 100% at the 1550-nm wavelength.

Pediatric obesity and its effects on asthma control.

Purpose: To explore if being overweight or obese influenced asthma control in pediatric patients ages 7-18 years with persistent asthma seen in an asthma specialty office.

Data Sources: A retrospective chart analysis of children with an asthma diagnosis seen within an asthma specialty practice from December 1, 2009 to May 31, 2010 was utilized. Normal weight, overweight, and obese children were compared.

A dual role of tobacco hexokinase 1 in primary metabolism and sugar sensing.

Hexokinase (HXK) is present in all virtually living organisms and is central to carbohydrate metabolism catalysing the ATP-dependent phosphorylation of hexoses. In plants, HXKs are supposed to act as sugar sensors and/or to interact with other enzymes directly supplying metabolic pathways such as glycolysis, the nucleotide phosphate monosaccharide (NDP-glucose) pathway and the pentose phosphate pathway. We identified nine members of the tobacco HXK gene family and observed that among RNAi lines of these nine NtHXKs, only RNAi lines of NtHXK1 showed an altered phenotype, namely stunted growth and leaf chlorosis.

Snakules: a model-based active contour algorithm for the annotation of spicules on mammography.

We have developed a novel, model-based active contour algorithm, termed "snakules", for the annotation of spicules on mammography. At each suspect spiculated mass location that has been identified by either a radiologist or a computer-aided detection (CADe) algorithm, we deploy snakules that are converging open-ended active contours also known as snakes. The set of convergent snakules have the ability to deform, grow and adapt to the true spicules in the image, by an attractive process of curve evolution and motion that optimizes the local matching energy.