Publications by authors named "Giersch B"
Article Synopsis
- Endothelin causes strong, lasting constriction of liver sinusoids after ischemia, resulting in local hypoxia and liver damage.
- The study tested the endothelin receptor antagonist bosentan in rats to see if it could prevent this constriction and improve liver recovery.
- The results showed that bosentan reduced liver enzyme levels indicative of injury and improved oxygen levels in liver tissue after ischemia, suggesting it helps protect the liver from damage.
Unlabelled: One mechanism evoked by ischemia is endothelin mediated vasoconstriction of the hepatic vascular bed. Postischemic sinusoidal constriction leads to microcirculatory disturbances and reduced blood flow, thereby causing local hypoxia and liver damage. The aim of the study was to avoid the constrictive response of sinusoids by blocking endothelin receptors.
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