Quantification of antibiotic usage against Streptococcus suis in weaner pigs in the Netherlands between 2017 and 2021.

Streptococcus suis is an important pig pathogen that can cause severe disease in the post-weaning period. As there are no commercial vaccines available in the Netherlands, antibiotic treatment is often necessary to control disease. S.

Supporting follow-up care in colorectal cancer patients: first experiences with the Assessment of Burden of ColoRectal Cancer (ABCRC)-tool.

Purpose: The Assessment of Burden of ColoRectal Cancer (ABCRC)-tool is a unique tool that includes a PROM focused on health-related quality of life (HRQoL), functional outcomes and lifestyle assessment. Furthermore, it provides visualization of results and treatment advice. The tool aims to support follow-up consultations of colorectal cancer (CRC) patients.

The Assessment of Burden of ColoRectal Cancer (ABCRC)-tool; a validity and reliability study.

Introduction: Follow-up care after treatment for colorectal cancer (CRC) is increasingly focused on health-related quality of life (HRQoL) and functional outcomes. The Assessment of Burden of ColoRectal Cancer (ABCRC)-tool is developed to measure these outcomes and support patient-oriented care. The tool comprises items assessing burden of disease and lifestyle parameters.

The patient perspective on the preoperative colorectal cancer care pathway and preparedness for surgery and postoperative recovery-a qualitative interview study.

Background And Objectives: This study aimed to explore colorectal cancer (CRC) patients' perspectives and experiences regarding the preoperative surgical care pathway and their subsequent preparedness for surgery and postoperative recovery.

Methods: CRC patients were recruited using purposive sampling and were interviewed three times (preoperatively, and 6 weeks and 3 months postoperatively) using semistructured telephone interviews. Interviews were audiotaped, transcribed verbatim and analysed independently by two researchers using thematic analysis with open coding.

Two cases of vascular complications after urologic robotic surgery.

Peripheral arterial disease (PAD) of the lower extremity is common and includes aortoiliac occlusive disease (AIOD). Moreover, prostate cancer is the most common cancer in men and is now treated with surgical robotic-assisted procedures. This paper overviews two cases of limb ischemia after robotic-assisted radical prostatectomy (RARP) and their resolution.

A case-control comparative study between Toupet-Sleeve and conventional sleeve gastrectomy in patients with preoperative gastroesophageal reflux.

Introduction: The aim of that study was to compare outcomes after Toupet-Sleeve (T-Sleeve) and sleeve gastrectomy (SG) as primary bariatric procedures in obese patients presenting with preoperative gastro-esophageal reflux disease (GERD).

Material And Methods: The outcomes of 19 consecutive patients operated between 2017 and 2019 by T-Sleeve were compared to the outcomes of 38 patients operated in 2014 by SG. The two groups were matched by age, sex, ASA classification, BMI, food habits and severity of esophagitis.

Use of a Decision Support Tool on Prognosis of Work Ability in Work Disability Assessments: An Experimental Study Among Insurance Physicians.

Purpose Assessment of prognosis of work disability is a challenging task for occupational health professionals. An evidence-based decision support tool, based on a prediction model, could aid professionals in the decision-making process. This study aimed to evaluate the efficacy of such a tool on Dutch insurance physicians' (IPs) prognosis of work ability and their prognostic confidence, and assess IPs' attitudes towards use of the tool.

Obstacle: A Tool to Assess the Home Environment Designed for All.

Introduction: Elderly prefer to live as long as possible independent in their own home. The occupational therapist can play an important role in this, for instance by giving advice regarding home adaptations or the use of assistive technology in order for the person to function more independently. There is need for a tool that allow to screen the home easily and thorough.

Extrapancreatic effects of incretin hormones: evidence for weight-independent changes in morphological aspects and oxidative status in insulin-sensitive organs of the obese nondiabetic Zucker rat (ZFR).

Incretin-based therapies are widely used to treat type 2 diabetes. Although hypoglycemic actions of incretins are mostly due to their insulinotropic/glucagonostatic effects, they may also influence extrapancreatic metabolism. We administered exendin-4 (Ex-4), a long-acting glucagon-like peptide receptor agonist, at low dose (0.

Endovascular resection of the native aortic valve before transcatheter aortic valve implantation: state of the art and review.

Transcatheter aortic valve implantation was introduced into clinical practice in 2002 as a rescue approach in patients presenting with symptomatic severe aortic stenosis but not eligible for conventional aortic valve replacement. This technique allows implantation of a balloon expandable bioprosthesis without resection of the native aortic valve. Several complications are described as a consequence of the residual highly calcified valve being squeezed against the aortic wall by the stent of the implant.

Hemostatic alterations during coronary artery bypass grafting.

Introduction: The origination of blood loss after cardiac surgery is not fully explained, but is related to operation trauma and use of cardiopulmonary bypass (CPB). However, the extent of their contribution is incompletely known and might differ between distinct operation procedures.

Materials And Methods: Three groups of CABG procedures were studied: 1) off-pump coronary artery bypass surgery (OPCAB, n=11) without CPB, 2) CABG with use of CPB (CABG, n=11) and 3) CABG with use of CPB combined with aortic valve replacement (AVR, n=11).

Continuous Postoperative Pericardial Flushing: A Pilot Study on Safety, Feasibility, and Effect on Blood Loss.

Background: Prolonged or excessive blood loss is a common complication after cardiac surgery. Blood remnants and clots, remaining in the pericardial space in spite of chest tube drainage, induce high fibrinolytic activity that may contribute to bleeding complications. Continuous postoperative pericardial flushing (CPPF) with an irrigation solution may reduce blood loss by preventing the accumulation of clots.

Multicentre randomized clinical trial to investigate the cost-effectiveness of an allogeneic single-donor fibrin sealant after coronary artery bypass grafting (FIBER Study).

Background: Reduction of blood transfusion in cardiac surgery is an important target. The aim of this study was to investigate the cost-effectiveness of the use of CryoSeal®, an allogeneic single-donor fibrin sealant, in patients undergoing coronary artery bypass grafting (CABG).

Methods: This randomized clinical study involved seven cardiac surgery centres in the Netherlands.

Stopping antiplatelet medication before coronary artery bypass graft surgery: is there an optimal timing to minimize bleeding?

Objectives: As the indication for antiplatelet medication expands, patients may be exposed to an increased risk of excessive blood loss when cardiac surgery is required. The optimal timing to stop acetylsalicylic acid (ASA) or ASA combined with clopidogrel (ASA+Clo) before surgery is the subject of controversy.

Methods: A total of 1065 patients were selected from a prospective randomized study on the effect of a fibrin sealant application in coronary artery bypass graft surgery [Fibrin sealant Induced Blood Exposure Reduction study;

Registration Number: NTR1386 (http://www.

Fibrinogen reduction and coagulation in cardiac surgery: an investigational study.

Fibrinogen as precursor of fibrin plays an essential role in clot formation. There are three main mechanisms associated with a reduction in fibrinogen concentration during cardiac surgery: hemodilution, consumption, and degradation. Moreover, early fibrinogen degradation products (FgDPs) can interfere with normal fibrin formation of intact fibrinogen.

The effects of pre- and postoperative fibrinogen levels on blood loss after cardiac surgery: a systematic review and meta-analysis.

Objectives: Fibrinogen concentrate is increasingly used in cardiac surgery when bleeding is anticipated or ongoing. Since randomized clinical studies to support this are lacking, it is relevant to know whether lower fibrinogen levels are associated with excessive bleeding. We performed a systematic review and meta-analysis to define the association between fibrinogen levels and blood loss after cardiac surgery.

Ambulatory oximetry fails to predict survival in chronic obstructive pulmonary disease with mild-to-moderate hypoxaemia.

Background And Objective: Although long-term oxygen therapy is one of few treatments known to improve survival in COPD, no patient subgroup likely to derive benefit has been identified in over 30 years. We assessed the prognostic value of point measurement of P(a) O(2) and proportion of ambulatory oximetry with saturations below 90% in this context.

Methods: Subjects were community-living patients with COPD and P(a) O(2) 56-70 mm Hg when stable.

Visuomotor coordination is different for different directions in three-dimensional space.

In most visuomotor tasks in which subjects have to reach to visual targets or move the hand along a particular trajectory, eye movements have been shown to lead hand movements. Because the dynamics of vergence eye movements is different from that of smooth pursuit and saccades, we have investigated the lead time of gaze relative to the hand for the depth component (vergence) and in the frontal plane (smooth pursuit and saccades) in a tracking task and in a tracing task in which human subjects were instructed to move the finger along a 3D path. For tracking, gaze leads finger position on average by 28 ± 6 ms (mean ± SE) for the components in the frontal plane but lags finger position by 95 ± 39 ms for the depth dimension.

Sequenced subjective accents for brain-computer interfaces.

Subjective accenting is a cognitive process in which identical auditory pulses at an isochronous rate turn into the percept of an accenting pattern. This process can be voluntarily controlled, making it a candidate for communication from human user to machine in a brain-computer interface (BCI) system. In this study we investigated whether subjective accenting is a feasible paradigm for BCI and how its time-structured nature can be exploited for optimal decoding from non-invasive EEG data.

Shared mechanisms in perception and imagery of auditory accents.

Objective: An auditory rhythm can be perceived as a sequence of accented (loud) and non-accented (soft) beats or it can be imagined. Subjective rhythmization refers to the induction of accenting patterns during the presentation of identical auditory pulses at an isochronous rate. It can be an automatic process, but it can also be voluntarily controlled.

Inability of single resting arterial blood gas to predict significant hypoxaemia in chronic obstructive pulmonary disease.

Background: While point measurement of resting arterial partial pressure of oxygen (P(a)O(2)) is the traditional gold-standard for assessment of oxygenation in chronic obstructive pulmonary disease (COPD), 24-h oximetry may identify further patients with clinically significant hypoxaemia. We aimed to describe the relationship between these two parameters and identify other correlated variables.

Methods: All patients registered with the Barwon Health Hospital Admission Risk Program from 1 March to 31 October 2008 for the diagnosis of COPD were identified.

Transient and steady-state responses to mechanical stimulation of different fingers reveal interactions based on lateral inhibition.

Objective: Simultaneous tactile finger stimulation evokes transient ERP responses that are smaller than the linear summation of ERP responses to individual stimulation. Occlusion and lateral inhibition are two possible mechanisms responsible for this effect. The present study disentangles these two effects using steady-state somatosensory evoked potentials (SSSEP).

Growth-dependent modulation of capacitative calcium entry in normal rat kidney fibroblasts.

Normal rat kidney (NRK) fibroblasts have electrophysiological properties and intracellular calcium dynamics that are dependent upon their growth stage. In the present study we show that this differential behavior coincides with a differential calcium entry that can be either capacitative or non-capacitative. Confluent cells made quiescent by serum deprivation, which have a stable membrane potential near -70 mV and do not show spontaneous intracellular calcium oscillations, primarily exhibit the capacitative mechanism for calcium entry, also called store-operated calcium entry (SOCE).