Induction of telomere shortening and cellular apoptosis by sodium meta-arsenite in human cancer cell lines.

The present study assessed the cytotoxicity of sodium meta-arsenite (SMA) on telomere shortening and cellular apoptosis in human A-549, MDA-MB-231 and U87-MG cancer cell lines. Following 2 weeks of 1 μM SMA treatment, population doubling time (PDT) was significantly ( < .05) increased by the inhibition of cell proliferation in all the cancer cell lines compared to that in untreated controls.