Publications by authors named "Gideon J Haber"
Rab-GTPases and their interacting partners are key regulators of secretory vesicle trafficking, docking, and fusion to the plasma membrane in neurons and neuroendocrine cells. Where and how these proteins are positioned and organized with respect to the vesicle and plasma membrane are unknown. Here, we use correlative super-resolution light and platinum replica electron microscopy to map Rab-GTPases (Rab27a and Rab3a) and their effectors (Granuphilin-a, Rabphilin3a, and Rim2) at the nanoscale in 2D.
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- Clathrin-mediated endocytosis is the main method that cells use to bring in receptors and other cargo, involving a structured clathrin lattice that forms on the membrane.
- The research employs advanced microscopy techniques to uncover the structural characteristics of this process, revealing that clathrin sites keep a consistent surface area during membrane bending across various cell types.
- The findings suggest that clathrin can naturally curve into pits without needing extra energy, with its curvature driven by specific structural features of the lattice, leading to a new model for understanding how this process works universally.