Coenzyme Q10 content in follicular fluid and its relationship with oocyte fertilization and embryo grading.

Background: No data are available on the presence and content of Coenzyme Q10 (CoQ10) in human follicular fluid and its role.

Objective: To assess the presence and concentration of CoQ10 in human follicular fluid in relation to oocyte fertilization.

Methods: CQ10 content was measured in follicular fluid obtained from 20 infertile women undergoing ovarian stimulation program for in vitro fertilization.

Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial.

Objective: To evaluate the effectiveness of coenzyme Q(10) treatment in improving semen quality in men with idiopathic infertility.

Design: Placebo-controlled, double-blind randomized trial.

Setting: Andrology Unit, Department of Internal Medicine, Polytechnic University of Marche, Italy.

Oleoylethanolamide protects human sperm cells from oxidation stress: studies on cases of idiopathic infertility.

N-acylethanolamides are naturally occurring hydrophobic molecules usually present in a very small amount in many mammalian tissues and cells. The presence of N-acylethanolamides has also been demonstrated in human reproductive tracts and fluids, although their biological effects and molecular mechanisms of action are not yet completely elucidated. It is known that some N-acylethanolamides, such as oleoylethanolamide, have antioxidative properties.

Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study.

Objective: To clarify a potential therapeutic role of coenzyme Q(10) (CoQ(10)) in infertile men with idiopathic asthenozoospermia.

Design: Open, uncontrolled pilot study.

Patient(s): Infertile men with idiopathic asthenozoospermia.

Structural damage induced by peroxidation may account for functional impairment of heavy synaptic mitochondria.

Coenzyme Q distribution, as well as respiratory chain features, in rat brain mitochondria depend on mitochondrial subpopulation, brain region and age. Heavy mitochondria (HM) usually display the lowest content of respiratory components and the lowest enzymatic activities and it has been suggested that they represent the oldest mitochondrial population. In this study, we confirmed that HM are considerably compromised in their structure.

Reduction of 1,4-quinone and ubiquinones by hydrogen atom transfer under UVA irradiation.

1,4-Benzoquinone, coenzyme Q0 and Q10 were reacted with a series of hydrogen donors in the ESR cavity in the presence or absence of UVA irradiation. The signals of the radicals generated from the hydrogen donors or of those of the semiquinones were detected. The reaction mechanism was interpreted by a hydrogen atom transfer instead of the usual electron transfer mechanism on the basis of the redox potentials of the reactants and the Marcus theory.