Publications by authors named "Giannicola G"

Objectives: Coronal deformities of the knee in skeletally immature patients are often physiological and resolve spontaneously. When this is not the case a surgical correction is required. As limited data are available on the effectiveness of the different surgical procedures to correct coronal deformities in skeletal immature patients, a systematic review was conducted to analyse the surgical outcomes, complications and recurrent deformity rate in idiopathic and pathologic coronal deformities.

View Article and Find Full Text PDF
Article Synopsis
  • Multiple fractures of the femur, defined as three or more non-contiguous fractures on the same bone segment, are rare and not well-documented in existing literature, with few studies addressing the topic.
  • The study presents the case of a 36-year-old man who suffered multiple severe femur fractures following a high-energy vehicular accident and underwent successful surgical treatment.
  • The paper aims to share the authors' treatment experience and outcomes while proposing a treatment algorithm, as well as to review existing literature on complex femur fractures.
View Article and Find Full Text PDF

Purpose: The primary aim of the present study was to assess the prevalence of chronic lesions of the central band of the interosseous membrane (cbIOM) in complex elbow instability (CEI) in a consecutive series of patients who had previously undergone surgical treatment for Mason II and III radial head (RH) fractures. The secondary aim was to define its clinical significance.

Methods: We performed a retrospective study on a prospective database.

View Article and Find Full Text PDF

Objective: Vagus nerve stimulation (VNS) Therapy is routinely indicated for people with drug-resistant epilepsy (DRE). We analyzed the baseline characteristics of individuals receiving the recently released VNS models and identified factors associated with early or late implantation.

Methods: The Comprehensive Outcomes Registry of subjects with Epilepsy (CORE-VNS), a prospective observational study evaluating the clinical and psychosocial outcomes of VNS Therapy®, is following participants for up to 60 months after VNS implantation.

View Article and Find Full Text PDF

Stress shielding (SS) around press-fit radial head arthroplasty (RHA) was recently reported as a cause of a new type of proximal radial neck resorption (PRNR). Very few studies have analyzed this phenomenon. No comprehensive classification is currently available.

View Article and Find Full Text PDF

Brain derived neurotrophic factor (BDNF) is a neurotrophin, expressed in the central nervous system and in peripheral tissues, that is regulated by the Gsα/cAMP pathway. In bone, it regulates osteogenesis and stimulates RANKL secretion and osteoclast formation in osteolytic tumors such as Multiple Myeloma. Fibrous dysplasia (FD) of bone is a rare genetic disease of the skeleton caused by gain-of-function mutations of the Gsα gene in which RANKL-dependent enhanced bone resorption is a major cause of bone fragility and clinical morbidity.

View Article and Find Full Text PDF

Purpose: In cruciate retaining total knee arthroplasty, posterior cruciate ligament damage may occur during tibial cutting. A prospective randomized study was conducted to investigate whether a novel tibial cutting technique was more effective than the currently used techniques.

Materials And Methods: Patients undergoing cruciate retaining total knee arthroplasty were recruited in a prospective, randomized, controlled trial.

View Article and Find Full Text PDF

Aims: The aim of this study was to analyze how proximal radial neck resorption (PRNR) starts and progresses radiologically in two types of press-fit radial head arthroplasties (RHAs), and to investigate its clinical relevance.

Methods: A total of 97 patients with RHA were analyzed: 56 received a bipolar RHA (Group 1) while 41 received an anatomical implant (Group 2). Radiographs were performed postoperatively and after three, six, nine, and 12 weeks, six, nine, 12, 18, and 24 months, and annually thereafter.

View Article and Find Full Text PDF

Vagus nerve stimulation (VNS) was the first device-based therapy for epilepsy, having launched in 1994 in Europe and 1997 in the United States. Since then, significant advances in the understanding of the mechanism of action of VNS and the central neurocircuitry that VNS modulates have impacted how the therapy is practically implemented. However, there has been little change to VNS stimulation parameters since the late 1990s.

View Article and Find Full Text PDF

Introduction: Stemmed acetabular cups are suitable for reconstruction in case of important bone loss. Nevertheless, their use is not so common, because generally judged very invasive and technically difficult to implant. The aim of the present review is to verify the results of their use and to evaluate indications and complications.

View Article and Find Full Text PDF

Purpose: To perform a morphometric analysis of the distal humerus lateral column medullary canal (LCMC).

Methods: Fifty computed tomography(CTs) from 24 males and 26 females were examined. Two observers measured: (1) the capitellum sagittal (R) and axial (R) radii of curvature; (2) the sagittal(Sd) and coronal(Cd) diameters of the LCMC in 5 different disto-proximal sites spaced 4 mm apart; (3) the capitellum and LCMC axis offsets on the sagittal (capSO,axSO) and coronal (capCO,axCO) planes; (4) the sagittal (Si) and coronal (Ci) inclination of the LCMC axis.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates isolated olecranon fractures (IOFs) in 165 patients over a decade, revealing demographic trends and fracture patterns.
  • The average age of patients was 58.5 years, with differences in age distribution and injury mechanisms between men and women.
  • Results show that low-energy accidents were the primary cause of fractures, with seasonal variations in occurrence based on gender and age.
View Article and Find Full Text PDF

Introduction: In recent years, the use of constrained implants in complex primary TKA has gained popularity since these implants may better and more easily address severe instability present in complex primary cases (CPC). However, the need for a constrained TKA in CPC is controversial. We hypothesized that a standard TKA may be successful in most of CPC and that an intraoperative switching to a constrained device is rarely need even in the presence of severe instability and bone loss.

View Article and Find Full Text PDF

Purpose: Choosing the correct size of head component in radial head arthroplasty is often challenging, particularly in comminuted fractures, deformities, and revision surgery. The main aim of this study was to investigate possible correlations between radial head diameters and the morphometric parameters of the articular distal humerus in order to find mathematical equations that may be used to infer radial head dimensions indirectly.

Methods: We performed bilateral elbow magnetic resonance imaging on 39 healthy young subjects, comprising 19 women and 20 men, with a mean age of 28 years (range, 21-32 years).

View Article and Find Full Text PDF

Aims: It has been hypothesized that proximal radial neck resorption (PRNR) following press-fit radial head arthroplasty (RHA) is due to stress-shielding. We compared two different press-fit stems by means of radiographs to investigate whether the shape and size of the stems are correlated with the degree of PRNR.

Methods: The radiographs of 52 RHAs were analyzed both at 14 days postoperatively and after two years.

View Article and Find Full Text PDF

Background: While few studies analysed the diagnostic validity of preoperative radiographs in distinguishing between Vancouver type B1 and B2 periprosthetic femoral fractures (PFFs), no investigation has been conducted to assess the degree of diagnostic validity of preoperative radiographs in identifying the fracture course and planning the most appropriate treatment. We analysed the diagnostic validity of radiographs in detecting the fracture course and stem stability in Vancouver type B PFFs.

Methods: Vancouver type B PFFs with different fracture courses were randomly performed in 36 dried cadaveric femurs in which a femoral broach had previously been implanted.

View Article and Find Full Text PDF

Background: Chronic complex persistent elbow instability (CCPEI) is a condition that even expert elbow surgeons find challenging to treat. The results of the few studies that have dealt with the treatment of this condition are conflicting. We describe the surgical results of a consecutive prospective series of patients with CCPEI and provide a review of the recent literature.

View Article and Find Full Text PDF

Purpose: The accuracy of the tibial crest (TC) in guiding the mechanical alignment of the tibial component in total knee arthroplasty (TKA) has been investigated in a few studies on Asian patients. No study analyzed the anatomical variants of the TC. We analyzed the morphological types of the TC in cadaveric tibiae of Caucasian subjects and assessed whether the TC may be considered an accurate guide for the mechanical alignment of the tibial component in TKA.

View Article and Find Full Text PDF
Article Synopsis
  • Fibrous dysplasia (FD) is a bone disease caused by mutations in the GNAS gene that lead to excess production of the signaling molecule cAMP, affecting the development of skeletal stem/progenitor cells.
  • The mutation alters these cells' ability to differentiate into bone and fat cells, resulting in disorganized bone formation and changes in processes like blood vessel development and immune response.
  • A comparative analysis with craniofacial FD samples revealed consistent changes, such as increased production of specific proteins and factors related to fat metabolism, highlighting the complex impacts of the mutation on the skeletal system.
View Article and Find Full Text PDF

Aims: The aim of this study was to analyze the results of two radiocapitellar prostheses in a large case series followed prospectively, with medium-term follow-up.

Patients And Methods: A total of 31 patients with a mean age of 54 years (27 to 73) were analyzed; nine had primary osteoarthritis (OA) and 17 had post-traumatic OA, three had capitellar osteonecrosis, and two had a fracture. Overall, 17 Lateral Resurfacing Elbow (LRE) and 14 Uni-Elbow Radio-Capitellum Implant (UNI-E) arthroplasties were performed.

View Article and Find Full Text PDF

Background: Post-traumatic proximal radioulnar synostosis is a very rare and disabling condition whose surgical treatment has traditionally been viewed with pessimism. The results of the few case series in the literature are conflicting. Our aims were (1) to describe the clinical results of a case series treated surgically by a single elbow surgeon and (2) to review the literature.

View Article and Find Full Text PDF

The development of a periostin-rich microenvironment in areas associated with insult, orchestrating pathways of repair and rebuilding, is documented. Literature lacks information regarding the presence of periostin in the context of rotator cuff tear (RCT). 55 consecutive patients with RCT were enrolled.

View Article and Find Full Text PDF

Purpose: Several tapered stems with similar geometry and extensive hydroxyapatite coating have recently been introduced. It is not clear, however, whether they share the same design or whether they exhibit any difference that might affect their clinical performances. In this study, we analysed five tapered stems fully coated with hydroxyapatite to establish whether they exhibit similar geometric features and may therefore be used indifferently when a cementless stem is indicated.

View Article and Find Full Text PDF

Purpose: Relationship between shoulder adhesive capsulitis (AC) and hypercholesterolemia is known. The connecting link might be represented by the correlation between HDL and transforming growth factor beta (TGF-β): normally, HDLs stimulate TGF-β expression; the latter is employed in the development of fibrous tissue. We assess whether the presence of the Apo-A1-G75A-polymorphism, which is correlated to an enhanced HDL function, could be a risk factor for the genesis and severity of AC.

View Article and Find Full Text PDF

Background: Locking plates are the gold standard for treatment of 3-part humeral head fractures, although major complications range from 9% to 36%. Percutaneous techniques may allow vascular supply preservation, maintenance of fracture hematoma, scarce blood loss. Many configurations with Kirschner wires can be performed, generating confusion on result interpretation.

View Article and Find Full Text PDF