In vitro evidence for a new therapeutic approach in renal cell carcinoma.

Purpose: Renal cell carcinoma (RCC) is the most lethal among the common urologic malignancies, comprising 3% of all human neoplasias; approximately 40% of patients eventually die of cancer progression. One third of patients who present with metastatic disease and up to 40% treated for localized disease generally experience recurrence. RCCs are characterized by high resistance to chemo-, radio- and immunotherapy.

Transurethral resection of prostate: technical progress and clinical experience using the bipolar Gyrus plasmakinetic tissue management system.

Background: The efficacy and safety of a new transurethral endoscopic device using bipolar electrocautery, the Gyrus system, were evaluated. This system permits rapid prostate tissue removal by endoscopic vaporization with little bleeding using saline irrigation, therefore eliminating transurethral resection of the prostate (TURP) syndrome.

Methods: Between January 2000 and December 2006 a total of 401 patients with benign prostatic hyperplasia underwent transurethral resection of the prostate utilizing the Gyrus device.

Retropubic versus perineal radical prostatectomy in early prostate cancer: eight-year experience.

Background: Prostate cancer is the most common malignancy in men and the second leading cause of cancer death. A randomized study was performed on patients with localized prostate cancer and treated with radical prostatectomy using the perineal or the retropubic approach comparing oncological outcomes, cancer control, and functional results.

Study Design: Between 1997 and 2004, in a randomized study 200 patients underwent a radical prostatectomy performed by retropubic (100 patients) or perineal (100 patients) approach.

Prostatic capsule- and nerve-sparing cystectomy in organ-confined bladder cancer: preliminary results.

We present a novel radical cystectomy technique that allows bladder cancer control while maintaining urinary continence and reducing the risk of erectile dysfunction by sparing the prostatic capsule and the neurovascular bundles. Between September 1997 and December 2002, 85 men were candidates for cystectomy; 32 were selected for a prostatic capsule- and seminal-sparing cystectomy with orthotopic urinary diversion. All patients had clinical organ-confined bladder cancer (cT1 to cT3a).