[ECT: remains of a gone era or aging tool for the future].

Electroconvulsive therapy is nowadays a very well codified treatment, safe and effective. In spite of this, its use remains scarce in the French speaking part of Switzerland, and fuels passionate and irrational discussions. A case record, and the written account of the patient, introduces a recall of the history and present state of this technique.

Nonresponse to clozapine and ultrarapid CYP1A2 activity: clinical data and analysis of CYP1A2 gene.

Clozapine (CLO), an atypical antipsychotic, depends mainly on cytochrome P450 1A2 (CYP1A2) for its metabolic clearance. Four patients treated with CLO, who were smokers, were nonresponders and had low plasma levels while receiving usual doses. Their plasma levels to dose ratios of CLO (median; range, 0.

Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity.

Objective: We investigated whether the oral administration of a low dose (75 micro g) of midazolam, a CYP3A probe, can be used to measure the in vivo CYP3A activity.

Methods: Plasma concentrations of midazolam, 1'OH-midazolam and 4'OH-midazolam were measured after the oral administration of 7.5 mg and 75 micro g midazolam in 13 healthy subjects without medication, in four subjects pretreated for 2 days with ketoconazole (200 mg b.