Publications by authors named "Giannakopoulos S"

Müllerianosis of the urinary bladder is a rare pathological condition involving ectopic Müllerian-derived tissues within the bladder. Despite its benign nature, due to its ability to mimic malignant conditions such as bladder carcinoma, diagnosis might be challenging. In this review, data from 36 cases across 32 studies were analyzed, focusing on patient demographics, symptomatology, diagnostic imaging, and histopathological features.

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Compromised male reproductive health, including reduced testosterone and sperm count, is one of the long COVID symptoms in individuals recovering from mild-severe disease. COVID-19 patients display testicular injury in the acute stage and altered serum fertility markers in the recovery phase, however, long-term implications on the testis remain unknown. This study characterized the consequences of SARS-CoV-2 on testis function.

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Article Synopsis
  • The text discusses the diagnostic challenges of lesions in the urinary bladder, particularly focusing on endocervicosis, a rare condition characterized by benign infiltration of endocervical glands.
  • It emphasizes the importance of thorough preoperative assessment for accurate diagnosis and highlights the potential association with adenocarcinoma, stressing the need for careful management.
  • A case study of a 47-year-old woman illustrates the surgical approach of segmental cystectomy with tumor-only excision, which was confirmed as endocervicosis through histopathological analysis, showcasing the importance of tailored surgical interventions for better patient outcomes.
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  • Researchers developed a long COVID mouse model to explore neutrophil behavior during the recovery phase of COVID-19, filling gaps in knowledge due to the difficulty of studying human lung tissues.
  • The study found that neutrophil recruitment and the formation of neutrophil extracellular traps remained active in the lungs for up to 30 days after infection.
  • These neutrophil activities were linked to ongoing lung injury, including fibrosis and inflammation, indicating potential long-term effects of COVID-19 on lung health.
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  • Diagnostic ureteroscopy (dURS) is a valuable optional procedure for assessing patients with upper tract urothelial carcinoma (UTUC), particularly for obtaining tissue samples for histology.
  • Data from the CROES-UTUC registry, analyzing 2380 patients, showed that dURS with biopsy was performed in 31.6% of cases, yielding adequate samples for diagnosis in 83.5% of situations, although about one-third of patients were under-staged.
  • High-grade biopsies effectively predicted high-grade and high-risk diseases with high accuracy, but low-grade tumors showed a significant number of patients with undetected high-risk disease, indicating a need for better diagnostic methods.
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This article reports a case of a 40-year-old woman with a history of myelomeningocele and neurogenic urinary incontinence who developed erosion and fistula formation following the placement of an artificial urinary sphincter (AUS) when she was 18 years old. The patient had a long-standing history of urinary incontinence that was unresponsive to prior surgeries for meningomyelocele. She reported the loss of uro-fecal material from the vagina but did not seek further medical evaluation until the age of 40.

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The hallmark of severe COVID-19 involves systemic cytokine storm and multi-organ injury including testicular inflammation, reduced testosterone, and germ cell depletion. The ACE2 receptor is also expressed in the resident testicular cells, however, SARS-CoV-2 infection and mechanisms of testicular injury are not fully understood. The testicular injury could be initiated by direct virus infection or exposure to systemic inflammatory mediators or viral antigens.

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Background: The evidence of prognostic factors and individualized surveillance strategies for upper tract urothelial carcinoma are still weak.

Objectives: To evaluate whether the history of previous malignancy (HPM) affects the oncological outcomes of upper tract urothelial carcinoma (UTUC).

Methods: The CROES-UTUC registry is an international, observational, multicenter cohort study on patients diagnosed with UTUC.

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Sexual transmission of Zika virus (ZIKV) is associated with virus persistence in the testes and shedding in the seminal fluid for months after recovery. We previously demonstrated that ZIKV can establish long-term replication without causing cytotoxicity in human Sertoli cells (SC), responsible for maintaining the immune privileged compartment of seminiferous tubules. Functional gene expression analyses also predicted activation of multiple virus sensing pathways including TLR3, RIG-I, and MDA5.

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Biochar has been obtained by pyrolysis of spent malt rootlets under limited oxygen supply and further activated by mixing with KOH and pyrolyzed again at high temperature. The total specific surface area of such activated biochar was 1148 m g, while that of micropores was 690 m g. This biochar was used to make a functional electrode by deposition on carbon cloth and was combined with a photoelectrochemical cell.

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Unlabelled: Purpose This study is to examine whether the term "trend toward statistical significance" is used to describe statistically nonsignificant results in biomedical literature. We examined articles published in five high-impact pediatric journals, including The Lancet Child & Adolescent Health, The Journal of Pediatrics, Early Human Development, Frontiers in Pediatrics, and BMC Pediatrics to identify manuscripts where a "trend" was used to describe a statistically nonsignificant result, from January 2020 to December 2021, and, furthermore, for The Journal of Pediatrics, Early Human Development, and BMC Pediatrics from January 2010 to December 2011. We detected that a "trend toward significance" was used to describe a statistically nonsignificant result at least once in 146 articles (2.

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Unlabelled: School closures were enforced as measures to restrain the COVID-19 pandemic, based on the assumption that young children may play a key role in SARS-CoV-2 spread. This study aims to determine the prevalence of SARS-CoV-2 IgG antibodies in children and corresponding parents, in order to improve surveillance and estimate the prevalence of asymptomatic or subclinical COVID-19 cases. A prospective multicenter study was conducted between March and June 2021 in Greece.

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The hallmark of severe COVID-19 involves systemic cytokine storm and multi-organ failure including testicular injury and germ cell depletion. The ACE2 receptor is also expressed in the resident testicular cells however, SARS-CoV-2 infection and mechanisms of testicular injury are not fully understood. The testicular injury can likely result either from direct virus infection of resident cells or by exposure to systemic inflammatory mediators or virus antigens.

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The extravesical spread of gas into the extraperitoneal space is an unusual complication of emphysematous cystitis and rarely, can reach remote areas of the body. Herein, we present the case of an immunosuppressed woman with emphysematous cystitis and extensive spread of extraperitoneal free gas up to the mediastinum.

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Background: Retrograde intrarenal surgery (RIRS) has become the preferred treatment modality for nephrolithiasis. However, because of ongoing uncertainties regarding the optimal perioperative management, operative technique, and postoperative follow-up, as well as a lack of standardization for outcome reporting, consensus is needed to achieve more uniform clinical practice worldwide.

Objective: To develop recommendations for RIRS on the basis of existing data and expert consensus.

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Article Synopsis
  • - Autosomal dominant polycystic kidney disease (ADPKD) is a genetic condition causing multiple cysts in kidneys, primarily due to mutations in the PKD1 and PKD2 genes that code for polycystin proteins.
  • - Researchers analyzed DNA from 90 kidney cysts from 24 patients, discovering that 93% of these cysts had harmful somatic mutations in PKD1 or PKD2, mainly resulting in significant gene alterations like truncations.
  • - The study suggests that cyst formation in ADPKD follows a cellular recessive mechanism, implicating both inherited and acquired mutations in the PKD1 and PKD2 genes within kidney cyst cells.
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Extracellular vesicles (EVs) have emerged as important players in all aspects of cancer biology. Their function is mediated by their cargo and surface molecules including proteins, lipids, sugars and nucleic acids. RNA in particular is a key mediator of EV function both in normal and cancer cells.

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Background: Hypospadias repair is a challenging type of urogenital reconstructive surgery for which different techniques are currently used. The purpose of this study is to determine the outcomes of distal, mid-shaft and proximal hypospadias repair using two new variations of tubularized incised plate (TIP) urethroplasty (TIP-δ and TIP-ελ) and to compare their complication rates with other already known operative techniques made from the same surgical team.

Methods: This study included 269 boys with hypospadias.

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Objective: Two conventional approaches for vesicovaginal fistula (VVF) repair are transabdominal repair for supratrigonal VVF and transvaginal approach for low lying fistulae. Laparoscopic surgery was introduced to duplicate the surgical steps of the transabdominal approach with reduction in morbidity. We report a series of patients treated with a modified laparoscopic technique which includes the use of only three trocars and a limited posterior cystotomy.

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The purpose of this study is to collect information on the bacterial resistance to antibiotics of bacteria isolated from urine cultures of patients treated for upper urinary tract calculi. Data of patients with urinary tract infection and urolithiasis were retrospectively reviewed to collect information on age, gender, stone size, location, hydronephrosis, procedure of stone removal and antibiotic treatment, identification and susceptibility of pathogens, symptoms, and infectious complications. A total of 912 patients from 11 centers in 7 countries (Bulgaria, Greece, Italy, North Macedonia, Spain, and Turkey) were studied.

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A bioprinting technique for large-scale, custom-printed immobilization of microalgae is developed for potential applications within architecture and the built environment. Alginate-based hydrogels with various rheology modifying polymers and varying water percentages are characterized to establish a window of operation suitable for layer-by-layer deposition on a large scale. Hydrogels formulated with methylcellulose and carrageenan, with water percentages ranging from 80% to 92.

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Background: Patients' views on the relative importance of treatment outcomes and medication attributes for type 2 diabetes may differ from clinicians' perceptions.

Objective: To assess which treatment outcomes and medication attributes are considered important by patients and clinicians for therapeutic decisions in type 2 diabetes.

Design: Exploratory, sequential, mixed-methods design comprising a qualitative (focus groups) and a quantitative (survey) phase.

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Purpose: To evaluate urinary stones using small-angle X-ray scattering (SAXS) and nitrogen porosimetry (NP). Traditionally, stones are categorized as hard or soft based on their chemical composition. We hypothesized that stone hardness is associated not only with its chemical composition but also with its internal architecture.

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Background: Kidney stone analysis techniques are well-established in the field of materials characterization and provide information for the chemical composition and structure of a sample. Nanomedicine, on the other hand, is a field with an increasing rate of scientific research, a big budget and increasingly developing market. The key scientific question is if there is a possibility for the development of a nanomedicine to treat kidney stones.

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Objective: To present a prospectively studied series of patients who underwent second-look flexible nephroscopy combined with holmium:yttrium-aluminum-garnet (Ho:YAG) laser lithotripsy under local anesthesia for residual stone removal after percutaneous nephrolithotomy (PCNL).

Materials And Methods: Thirty consecutive eligible patients who underwent a PCNL procedure in the previous 48-96 hours were included. The inclusion criteria were the following: (1) 1 or 2 residual stones 0.

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