Publications by authors named "Gianna Aurora Palumbo"
Article Synopsis
- - The study investigates how non-integrated viral DNAs, specifically from hepatitis B virus (HBV) and adenovirus type 5 (Ad5), position themselves in human liver cells' genomes using techniques like Hi-C and CHi-C.
- - HBV targets CpG islands associated with highly expressed genes and gene regulation during infection, while Ad5 DNA preferentially interacts with transcription start sites and enhancers of those genes.
- - These findings suggest that different DNA viruses have distinct strategies for integrating into the genome's 3D architecture, potentially influencing their own replication and altering the expression of host genes.
Article Synopsis
- A splice variant of the auxin response factor gene, identified as ARF8.4, has been isolated, which displays unique tissue-specific localization and impacts gene expression in flowers.
- Inducible expression of ARF8.4 in mutant flowers effectively rescues a short-stamen phenotype by restoring expression of a crucial regulator for stamen elongation, whereas other variants have minimal effects.
- ARF8.4 enhances the transcription of specific auxin-related genes and influences physiological processes like anther dehiscence and endothecium lignification through its binding to the promoters of these genes.
The HBV covalently closed circular DNA (cccDNA) is organized as a mini-chromosome in the nuclei of infected hepatocytes by histone and non-histone proteins. Transcription from the cccDNA of the RNA replicative intermediate termed pre-genome (pgRNA), is the critical step for genome amplification and ultimately determines the rate of HBV replication. Multiple evidences suggest that cccDNA epigenetic modifications, such as histone modifications and DNA methylation, participate in regulating the transcriptional activity of the HBV cccDNA.
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