Publications by authors named "Gianmarco Camazzola"
The indirect effect of radiation plays an important role in radio-induced biological damages. Monte Carlo codes have been widely used in recent years to study the chemical evolution of particle tracks. However, due to the large computational efforts required, their applicability is typically limited to simulations in pure water targets and to temporal scales up to the µs.
View Article and Find Full Text PDFArticle Synopsis
- - The proposed mechanism suggests that cancer cells can lower nuclear oxygen levels by manipulating cholesterol levels in their membranes, which affects oxygen diffusion without relying on hypoxic conditions, potentially aiding resistance to chemotherapy and radiotherapy.
- - High cholesterol content in cell membranes leads to more rigid structures, impeding oxygen diffusion and enabling cells to consume oxygen more rapidly than it can be replenished, thereby decreasing nuclear oxygen concentration.
- - Experimental analysis of bladder cancer cells during the cell cycle uses gene analysis and radiation response tests to demonstrate a correlation between cellular and nuclear oxygen levels, showing that oxygen presence significantly influences DNA damage from radiation.