Publications by authors named "Gianluca Merello Oyarzun"
Commun Biol
December 2023
Article Synopsis
- Lysine-specific demethylase 1A (LSD1) interacts with REST corepressor (RCOR) proteins to modify histones, influencing transcription regulation based on the specific RCOR present in the complex.
- The study reveals that RCOR genes originated from two rounds of whole-genome duplications in early vertebrate evolution, while LSD genes date back to before the split between animals and plants.
- By using bioinformatics, researchers traced the evolution of the LSD1-RCOR complex and suggested that studying non-model animal species could enhance our understanding of this epigenetic interaction.
