Publications by authors named "Gianluca Deiana"
Non-valvular atrial fibrillation (AF) and cerebral amyloid angiopathy (CAA) are two common diseases in elderly populations. Despite the effectiveness of oral anticoagulant therapy in cardioembolic stroke prevention, intracranial hemorrhage represents the most serious complication of these therapies. Cerebral amyloid angiopathy is one of the main risk factors for spontaneous intracranial bleeding, and this risk is highly increased by age and concomitant antithrombotic therapies.
View Article and Find Full Text PDFArticle Synopsis
- - An adult psychiatric patient experienced new focal bilateral motor seizures after abruptly stopping chronic lormetazepam use and overdosing on amitriptyline, despite not showing typical symptoms of amitriptyline intoxication.
- - Video-EEG recordings showed a specific pattern of motor activity, but the EEG remained normal, which raised the possibility of nonepileptic seizures due to the patient's psychiatric history and preserved awareness during convulsions.
- - The case highlights the complexity of diagnosing focal bilateral motor seizures during benzodiazepine withdrawal, especially when they can resemble nonepileptic seizures in patients with mental health issues.
Complications of mechanical thrombectomy for acute ischemic stroke: Incidence, risk factors, and clinical relevance in the Italian Registry of Endovascular Treatment in acute stroke.
Int J Stroke
October 2021
Background: There are limited data concerning procedure-related complications of endovascular thrombectomy for large vessel occlusion strokes.
Aims: We evaluated the cumulative incidence, the clinical relevance in terms of increased disability and mortality, and risk factors for complications.
Methods: From January 2011 to December 2017, 4799 patients were enrolled by 36 centers in the Italian Registry of Endovascular Stroke Treatment.
Objectives: The aim of this study was to investigate the outcomes of left atrial appendage occlusion (LAAO) in high bleeding risk patients suffering atrial fibrillation (AF) and to analyze the different antithrombotic therapies following the intervention.
Background Methods: This monocentric study included 68 patients with nonvalvular AF with an absolute contraindication to OAT or at high bleeding risk. Follow-up was done with a clinical visit at 3-6-12 months.
Intracranial hemorrhage (ICH) is the major complication of oral anticoagulant therapy. Cerebral amyloid angiopathy (CAA) is an age-related disease characterized by the pathological deposition of β-amyloid protein in leptomeningeal and cortical cerebral vessels. Such vascular alterations expose to the risk of spontaneous vascular rupture.
View Article and Find Full Text PDFPatients lying in a vegetative state present severe impairments of consciousness [1] caused by lesions in the cortex, the brainstem, the thalamus and the white matter [2]. There is agreement that this condition may involve disconnections in long-range cortico-cortical and thalamo-cortical pathways [3]. Hence, in the vegetative state cortical activity is 'deafferented' from subcortical modulation and/or principally disrupted between fronto-parietal regions.
View Article and Find Full Text PDFObjective: To identify the clinical and radiologic features that should raise suspicion for the pseudotumoral presentation of cerebral amyloid angiopathy-related inflammation (CAA-I).
Methods: We retrospectively reviewed the characteristics of 5 newly diagnosed and 23 previously reported patients in whom the CAA-I imaging findings were initially interpreted as CNS neoplasms.
Results: Most cases (85%) occurred in patients >60 years old.
Article Synopsis
- The study aimed to explore MRI factors linked to blood-brain barrier (BBB) changes during the acute phase of ischemic stroke.
- Researchers analyzed MRI scans of 44 patients, focusing on contrast enhancement to identify BBB changes and other factors like lesion volume.
- They found that BBB changes were rare in the first 3 hours (only 3%), but after 3 hours, significant alterations were noted, particularly linked to presence of FLAIR positivity, suggesting the involvement of vasogenic edema.
The feeling of being excluded from a social interaction triggers social pain, a sensation as intense as actual physical pain. Little is known about the neurophysiological underpinnings of social pain. We addressed this issue using intracranial electroencephalography in 15 patients performing a ball game where inclusion and exclusion blocks were alternated.
View Article and Find Full Text PDFBackground: WHO grade II gliomas are often approached by radiation therapy (RT). However, little is known about tumor response and its potential impact on long-term survival.
Patients And Methods: Patients subjected to RT were selected from the own database of WHO grade II gliomas diagnosed between 1991 and 2000.
Purpose: This study was conducted to elucidate the impact of loss of heterozygosity (LOH) for chromosomes 1p36 and 19q13 on the overall survival of patients with diffusely infiltrating WHO grade 2 gliomas treated without chemotherapy.
Patients And Methods: We assessed the LOH status of tumors from patients harboring WHO grade 2 gliomas diagnosed between 1991 and 2000. Patients were either followed after initial biopsy or treated by surgery and/or radiation therapy (RT).