Publications by authors named "Gianlorenzo Fagiolo"
Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial.
Lancet Neurol
February 2016
Article Synopsis
- Moderate cooling post-birth asphyxia has been shown to reduce death and disability, and researchers explored the potential added benefits of xenon gas in combination with this treatment.
- A trial involving 92 infants was conducted to assess the effectiveness of total body hypothermia plus xenon against standard cooling treatment, with specific neurological outcomes measured within 15 days after birth.
- The trial, completed in 2014, randomly assigned infants to either standard cooling or cooling with xenon, aiming to determine if the latter could improve brain health outcomes after asphyxia.
Clinical picture archiving and communications systems provide convenient, efficient access to digital medical images from multiple modalities but can prove challenging to deploy, configure and use. MRIdb is a self-contained image database, particularly suited to the storage and management of magnetic resonance imaging data sets for population phenotyping. It integrates a mature image archival system with an intuitive web-based user interface that provides visualisation and export functionality.
View Article and Find Full Text PDFIn the rodent brain the hemodynamic response to a brief external stimulus changes significantly during development. Analogous changes in human infants would complicate the determination and use of the hemodynamic response function (HRF) for functional magnetic resonance imaging (fMRI) in developing populations. We aimed to characterize HRF in human infants before and after the normal time of birth using rapid sampling of the blood oxygen level dependent (BOLD) signal.
View Article and Find Full Text PDFAs population-based studies may obtain images from scanners with different field strengths, a method to normalize regional brain volumes according to intracranial volume (ICV) independent of field strength is needed. We found systematic differences in ICV estimation, tested in a cohort of healthy subjects (n=5) that had been imaged using 1.5T and 3T scanners, and confirmed in two independent cohorts.
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