Cytotoxic components from the leaves of Erythrophleum fordii induce human acute leukemia cell apoptosis through caspase 3 activation and PARP cleavage.

Cassaine diterpenoids as erythrofordins A-C (1-3), pseudo-erythrosuamin (4), and erythrofordin U (5) isolated from the leaves of Vietnamese Erythrophleum fordii Oliver were tested cytotoxic activity against human leukemia cancer cells. The results showed that these metabolites exhibited dose-dependent cytotoxicity against human leukemia HL-60 and KG cells with IC values ranging from 15.2 ± 1.

Oleanane-type triterpene saponins from leaves and their cytotoxic activity.

Two new, aramatosides A and B ( and ), together with seven known oleanane-type triterpene saponins (-) were isolated from the leaves of . Their structures were determined by combination of HR-ESI-MS, 1 D and 2 D NMR spectral data as well as comparison with the previous literature. Compounds - exhibited cytotoxic effects towards three human cancer cell lines (HT29, A2058, and A549) with IC values ranging from 2.

New lupane-type and ursane-type triterpene saponins from the leaves of .

Three new triterpene saponins including two lupane-types and an ursane-type were isolated from the leaves of . Their structures were determined as 2,3,23-trihydroxylup-20(29)-en-28-oic acid 3---L-arabinopyranoside (), 2,3,23-trihydroxylup-20(29)-en-28-oic acid 3--[-L-arabinopyranoside]-28--[-D-glucopyranosyl] ester (), and 2,3,23-trihydroxyurs-12-en-28-oic acid 3--[-L-arabinopyranoside]-28--[-D-glucopyranosyl(1→2)--D-glucopyranosyl] ester () by analysis of their HR-ESI-MS, 1D and 2D NMR spectra. The 2,3,23-trioxygenated pentacyclic triterpenes were uncommonly found in the nature.

Chemical Constituents of Chirita drakei.

Chirita drakei Burtt (now accepted as Primzina drakei (B.L.Burtt) Mich.