New Fusarochromanone Derivatives from the Marine Fungus UBOCC-A-117302.

Two new fusarochromanone derivatives, deacetylfusarochromene () and deacetamidofusarochrom-2',3-diene (), along with the previously reported metabolites fusarochromanone TDP-2 (), fusarochromene (), 2,2-dimethyl-5-amino-6-(2'-ene-4'-hydroxylbutyryl)-4-chromone (), fusarochromanone (), (-)-chrysogine (), and equisetin (), were isolated from the marine fungus UBOCC-A-117302. The structures of the compounds were determined by extensive spectrometric (HRMS) and spectroscopic (1D and 2D NMR) analyses, as well as specific rotation. Among them, and showed inhibition of three protein kinases with IC values ranging from 1.

Marine Bromotyrosine Derivatives in Spotlight: Bringing Discoveries and Biological Significance.

The Verongida order comprises several sponge families, such as Aplysinellidae, Aplysinidae, Ianthellidae, and Pseudoceratinidae, reported for producing bromotyrosine-derived compounds. First identified in 1913, bromotyrosine derivatives have since captivated interest notably for their antitumor and antimicrobial properties. To date, over 360 bromotyrosine derivatives have been reported.

Health system barriers to the implementation of the national action plan to combat antimicrobial resistance in Vietnam: a scoping review.

Background: Vietnam is among 11 countries in the Western Pacific region that has developed a National Action Plan for Antimicrobial Resistance (NAPCA).

Methods: This scoping review characterises health system barriers to the implementation of the Vietnam NAPCA, with reference to the WHO Health Systems Framework.

Results: Over 7 years, between 2013 and 2020, the Ministry of Health (MOH) of Vietnam has been implementing activities to achieve the six NAPCA objectives.

Characterization of thymol derivatives from Turcz. aerial parts.

From the aerial parts of , four thymol derivatives (-) were isolated and structurally elucidated by NMR and mass spectroscopic methods. Of which, a new dimeric thymol derivative () was characterized and its absolute configuration was established by electronic circular dichroism quantum method. In addition, the 1D and 2D NMR as well as HR-ESI mass spectral data of were provided for the first time.

Chemical constituents of Antidesma bunius aerial parts and the anti-AGEs activity of selected compounds.

Thirty-three natural products were isolated from the aerial parts of Antidesma bunius, Euphorbiaceae, a plant used in Vietnamese traditional medicine against rheumatoid arthritis. All compounds were reported the first time for this species, and nine constituents resembled undescribed natural products, noticeably three coumarinolignans with 2,2-dimethyl-1,3-dioxolane moiety, two cyclopeptides, and two furofuran-type lignans connected with a phenylpropanoid moiety. The individual structures were elucidated by combining NMR and MS data, and their configuration was established by NOESY and ECD experiments and NMR calculations.

Isolation of Sesquiterpenoids and Steroids from the Soft Coral and Determination of Their Absolute Configuration.

Two undescribed rearranged cadinane-type sesquiterpenoids (-), named sinulaketol A-B, together with one new chlorinated steroid (), one new gorgosterol (), one known sesquiterpene (), one known dibromoditerpene () and two known polyhydroxylated steroids (-) were isolated from the soft coral . The structures of these compounds were established by extensive spectroscopic analysis, including HRESIMS, 1D, and 2D NMR spectroscopy. Their absolute configurations were also determined by the ECD calculations and DP4+ probability analysis.

Ethnopharmacology, Phytochemistry, and Pharmacology of .

, which belongs to the Myrtaceae plant family, is widely distributed and cultivated in South East Asian countries. The decoction of leaves and flower buds has been consumed regularly as a beverage among the Vietnamese and Chinese communities. In addition, it has also been used in traditional medicine for a variety of purposes, notably for influenza, skin diseases, and digestive conditions.

Fissistigma genus - a review on phytochemistry and pharmacological activities.

The genus Fissistigma belongs to Annonaceae family and is mainly distributed in tropical areas of Asia. Many species from this genus have long been used for medicinal purposes in China and Vietnam. To date, there have been a number of studies on both phytochemical and pharmacological aspects of Fissistigma species, which indicated that the genus is a rich source of diverse and novel bioactive compounds, including alkaloids, terpenoids and phenolic derivatives.