Publications by authors named "Giang M Vu"
Despite the raised awareness of the role of pharmacogenomic (PGx) in personalized medicines for COVID-19, data for COVID-19 drugs is extremely scarce and not even a publication on this topic for post-COVID-19 medications to date. In the current study, we investigated the genetic variations associated with COVID-19 and post-COVID-19 therapies by using whole genome sequencing data of the 1000 Vietnamese Genomes Project (1KVG) in comparison with other populations retrieved from the 1000 Genomes Project Phase 3 (1KGP3) and the Genome Aggregation Database (gnomAD). Moreover, we also evaluated the risk of drug interactions in comorbid COVID-19 and post-COVID-19 patients based on pharmacogenomic profiles of drugs using a computational approach.
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- The study addresses the lack of research on skin-related genetic traits in underrepresented populations, specifically focusing on the Vietnamese population.
- Researchers developed a computational method to analyze genetic factors affecting 25 skin traits using both public and local Vietnamese genetic data.
- Findings showed that Vietnamese skin genetics are closely related to East Asian cohorts, revealing co-occurring traits like skin aging and collagen issues, contributing to a broader understanding of genetic diversity in skin health.
Background: A global pandemic has been declared for coronavirus disease 2019 (COVID-19), which has serious impacts on human health and healthcare systems in the affected areas, including Vietnam. None of the previous studies have a framework to provide summary statistics of the virus variants and assess the severity associated with virus proteins and host cells in COVID-19 patients in Vietnam.
Method: In this paper, we comprehensively investigated SARS-CoV-2 variants and immune responses in COVID-19 patients.