Publications by authors named "Giang Le Thi Thu"
Background: The effectiveness of the immunity provided by SARS-CoV-2 vaccines is an important public health issue. We analyzed the determinants of 12-month serology in a multicenter European cohort of vaccinated healthcare workers (HCW).
Methods: We analyzed the sociodemographic characteristics and levels of anti-SARS-CoV-2 spike antibodies (IgG) in a cohort of 16,101 vaccinated HCW from eleven centers in Germany, Italy, Romania, Slovakia and Spain.
Understanding antibody persistence concerning multimorbidity is crucial for vaccination policies. Our goal is to assess the link between multimorbidity and serological response to SARS-CoV-2 nine months post-first vaccine. We analyzed Healthcare Workers (HCWs) from three cohorts from Italy, and one each from Germany, Romania, Slovakia, and Spain.
View Article and Find Full Text PDFBrown adipose tissue (BAT) is a promising weapon to combat obesity and metabolic disease. BAT is thermogenic and consumes substantial amounts of glucose and fatty acids as fuel for thermogenesis and energy expenditure. To study BAT function in large human longitudinal cohorts, safe and precise detection methodologies are needed.
View Article and Find Full Text PDFArticle Synopsis
- The mature lipase LipA and its chaperone DeltaLipBhis were over-expressed in E. coli and effectively purified, with LipA displaying optimal activity between 50-55°C and maintaining significant activity up to 45°C.
- The enzyme exhibited optimal performance at pH 10.75 for hydrolyzing olive oil and remained stable in an alkaline pH range, while showing resistance to various organic solvents, demonstrating its potential for industrial applications.
- Metal ions had varying effects on lipase activity, with some enhancing and others inhibiting its function; the enzyme preferentially hydrolyzed triglycerides with shorter acyl chains and demonstrated significant activity with specific oils.