Oleanane-type saponins from Lysimachia laxa Baudo and their antibacterial activities.

Seven new oleanane-type triterpene saponins, lysimaponins A-G, were isolated from aerial parts of Lysimachia laxa Baudo. Their chemical structures have been elucidated by analysis of spectroscopic and chemical methods. All compounds were evaluated for their antibacterial effects against Microcystis aeruginosa, Vibrio parahaemolyticus, V.

Atractylodes macrocephala Rhizomes Contain Anti-inflammatory Sesquiterpenes.

Two new compounds, named eudesm-4(15),7-diene-3α,9β,11-triol (1) and eudesm-4(15),7-diene-1β,3α,9β,11-tetraol (2) together with three known sesquiterpene lactones (1S,5R,7R,10R)-secoatractylolactone (3), (1S,5R,7R,10R)-secoatractylolactone-11-O-β-D-glucopyranoside (4) atractylenolide III (5) were isolated from the rhizomes of Atractylodes macrocephala. Their structures were elucidated by using one-dimensional (1D) and 2D-NMR spectra and high resolution electrospray ionization (HR-ESI)-MS data. Compound 5 exhibited the most active anti-inflammatory activity with IC values of 27.

as a Model Fungus for Detecting Antifungal Activity of Botanicals: An Evaluation on Vietnamese Medicinal Plant Extracts.

Medicinal plants play important roles in traditional medicine, and numerous compounds among them have been recognized for their antimicrobial activity. However, little is known about the potential of Vietnamese medicinal plants for antifungal activity. In this study, we examined the antagonistic activity of twelve medicinal plant species collected in Northern Vietnam against , , , and .

Efficacy of Alpinumisoflavone Isolated from Fruit in Tumor Necrosis Factor-α-Induced Damage of Human Dermal Fibroblasts.

The skin is an important organ in the human body that protects the body from environmentally hazardous substances. Reactive oxygen species (ROS) cause inflammatory reactions and degradation of the extracellular matrix leading to skin aging and various cutaneous lesions. This study evaluated the potential of isoflavones isolated from fruit to prevent TNF-α-induced skin inflammation in normal human dermal fibroblasts (HDFs).

Multielement Analysis of Pakchoi ( L. ssp. ) by ICP-MS and Their Classification according to Different Small Geographical Origins.

Statistical interpretation of the concentrations of 42 elements, determined using solution-based inductively coupled plasma mass spectrometry (ICP-MS) analysis and multivariate statistical methods, such as principal components analysis (PCA), was used to establish the provenance of pakchoi ( L. ssp. ) from 6 areas in Ha Noi, Vietnam.

Metabolomics Approach for Discrimination and Quality Control of Natural and Commercial Products in Vietnam.

A precise HPLC-DAD-based quantification together with the metabolomics statistical method was developed to distinguish and control the quality of , a popular medicinal material in Vietnam. Multivariate statistical methods such as hierarchical clustering analysis and principal component analysis were utilized to compare and discriminate six natural and twelve commercial samples. 2,3,4',5-Tetrahydroxystilbene 2---D-glucopyranoside (THSG) , emodin , and the new compound 6-hydroxymusizin 8---D-apiofuranosyl-(1⟶6)--D-glucopyranoside could be considered as important markers for classification of Furthermore, seven phenolics were quantified that the variation in the contents of selected metabolites revealed the differences in the quality of natural and commercial samples.

4'‑O‑Methylalpinumisoflavone inhibits the activation of monocytes/macrophages to an immunostimulatory phenotype induced by 27‑hydroxycholesterol.

The epidemiological, animal and cell effects of plant metabolites suggest versatile health benefits of flavonoids. However, whether flavonoids affect the deleterious biological activity of oxygenated cholesterol molecules remains to be elucidated. The present study investigated the effects of 4'‑O‑methylalpinumisoflavone (mAI) isolated from Maclura tricuspidata (Cudrania tricuspidata) on the 27‑hydroxycholesterol (27OHChol)‑induced activation of monocytes/macrophages using human THP‑1 cells.