Publications by authors named "Giancarlo Palasciano"

Wounds in diabetic patients with peripheral arterial disease (PAD) may be poorly responsive to revascularization and conventional therapies. : This study's objective is to analyze the results of regenerative cell therapy with peripheral blood mononuclear cells (PBMNCs) as an adjuvant to revascularization. This study is based on 168 patients treated with endovascular revascularization below the knee plus three PBMNC implants.

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Purpose: Endovascular aortic repair (EVAR) is currently expanding its feasibility thanks to design innovations, but hostile proximal necks and narrow iliac arteries are still a constraint, as expressed by the Instructions for Use (IFU) of most devices. Our aim is to report the preliminary results of the E-Tegra endograft in infrarenal abdominal aortic aneurysms (AAAs) performed in 15 high-volume centers.

Materials And Methods: The e-Tegra Italian endoGraft REgistry (TIGRE) is a prospectively maintained database of consecutive EVAR with the E-Tegra stent-graft across 15 participating centers between March 2021 and March 2023.

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Article Synopsis
  • The study aimed to develop a predictive model (STRESS score) to identify high-risk patients for postoperative delirium (POD) following elective vascular surgery.
  • An observational retrospective analysis was conducted on 1,067 patients, finding a 10.4% incidence of POD, with significant risk factors identified through logistic regression.
  • The STRESS score demonstrated solid predictive ability for POD in the study groups, but further validation is required for clinical implementation.
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Introduction: In this study, we evaluated the role of preoperative inflammatory markers as Neutrophil-to-Lymphocyte (NLR) and Platelet-to-Lymphocyte (PLR) ratios in relation to post-endovascular aneurysm repair (EVAR) sac shrinkage, which is known to be an important factor for abdominal aortic aneurysm (AAA) healing.

Methods: This was a single-center retrospective observational study. All patients who underwent the EVAR procedure from January 2017 to December 2020 were eligible for this study.

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Background: Penumbra/Indigo aspiration thrombectomy Systems (Penumbra Inc.) in patients with acute lower limb ischemia (ALLI) is becoming a fundamental alternative to surgical and intra-arterial thrombolysis. The INDIAN UP trial represents the second phase of the Italian national multicenter trial evaluating the safety and effectiveness of the device in the treatment of ALLI.

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  • A multicenter retrospective study evaluated the early results and mid-term effectiveness of self-expanding covered stenting for external iliac artery occlusive disease from 2015 to 2021, using the Viabahn stent.
  • The study included 93 patients, primarily older males, with various conditions of limb discomfort and significant lesions; technical success was 100%, with a 1.4% perioperative death rate and 6.5% complications.
  • Results showed an impressive 89.8% primary patency at an average follow-up of 42 months; severe calcifications and tortuosity didn't significantly affect outcomes, but stents less than 8 mm in diameter were linked to poorer patency rates.
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Background: We present a standardized protocol of endovascular revascularization for patients with acute limb ischemia due to popliteal artery aneurysm (PAA) thromboembolic complication, based on the combination of vacuum-assisted thromboaspiration to improve tibiopedal outflow and covered stent graft to exclude the PAA.

Methods: All patients with a diagnosis of PAA complicated by thromboembolic events undergoing total endovascular rescue were prospectively enrolled in a dedicated database from November 2018 to November 2021. To assess vessel patency, the TIPI (Thromboaspiration In Peripheral Ischemia) classification was used.

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Our aim was to determine the predictive role of the preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in vascular access malfunctioning in patients who had undergone their first native arterio-venous fistula (AVF) for hemodialysis. Methods: This was a single-center retrospective observational study. All patients who underwent the procedure of the creation of a first native AVF for hemodialysis from January 2019 to December 2020 were considered eligible to be part of this study.

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Article Synopsis
  • Post-operative delirium (POD) is a frequent issue in older patients after vascular surgery, affecting 11.3% of those studied, leading to longer hospital stays and more reinterventions.
  • The research analyzed inflammatory markers (NLR, PLR, SII) against POD occurrence, finding that higher levels indicated a greater risk of developing delirium.
  • Factors like age, renal failure, and specific surgical procedures were identified as independent risk factors, suggesting that these biomarkers could assist in predicting and managing POD in vascular surgery patients.
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  • The Ovation Abdominal Stent Graft System, including its redesigned version called Ovation Alto, provides a new sealing option for repairing abdominal aortic aneurysms (AAA), with CE Mark approval granted in August 2020 for the Alto model.
  • This registry study aims to assess the outcomes of patients undergoing elective endovascular aneurysm repair (EVAR) using the Alto stent graft, with an estimated 300 participants across various centers over a 24-month enrollment period followed by a 5-year follow-up.
  • Key goals include evaluating the technical and clinical success of the procedure as well as analyzing factors such as operative time, radiation exposure, and the impact of patient characteristics and device configuration on outcomes.
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  • - Erectile dysfunction (ED) is the ongoing inability to achieve or maintain an erection suitable for sexual intercourse, and it shares common risk factors with cardiovascular diseases; however, its prevalence in patients with abdominal aortic aneurysm (AAA) is not well studied.
  • - This study explored how well preoperative information on sexual function is communicated to patients undergoing endovascular aneurysm repair (EVAR), assessing ED through the International Index of Erectile Function questionnaire and comparing results with pelvic artery health indicated by preoperative CTA scans.
  • - Out of 25 enrolled patients, the majority exhibited varying degrees of ED, with 80% showing moderate to severe pelvic arterial disease, demonstrating a significant relationship between the severity of pelvic vascular issues and the severity of
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Article Synopsis
  • The Ovation Alto endograft system, introduced after CE Mark approval in 2020, features a newly positioned sealing ring for improved endovascular aneurysm repair outcomes.
  • In a study involving 11 male patients with an average age of 75, the procedures showed no complications, with successful technical results and minimal blood loss and procedure time.
  • Follow-ups at one and six months revealed 100% clinical success, with no adverse events, indicating promising early results but highlighting the need for further research on long-term durability.
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Asherson's Syndrome, also defined as Catastrophic Antiphospholipid Syndrome (CAPS), represents the most severe manifestation of Antiphospholipid Antibody Syndrome. Rarely, the first CAPS diagnosis is based on macro-thrombotic event as acute limb ischemia. We present a case of a 65-year-old woman admitted with an acute lower limb arterial ischemia with a complete occlusion of all the three tibial vessels.

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Objective: In recent years, manufacturers have developed new stent grafts with lower profiles to increase the endovascular aneurysm repair applicability. As reported by the current European Society for Vascular Surgery guidelines, long-term evaluation of such low-profile platforms is strongly recommended. This study aims to report outcomes beyond 5 years from a multicenter registry, including a real-world cohort of patients electively treated with low-profile stent grafts.

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Intoduction: Familial cerebral cavernous malformations (FCCM) are a rare condition characterized by the multiple presences of cavernous malformations located in the central nervous system.

Case Description: We present a case of FCCM incidental diagnosis in a 71-year-old male patient who underwent carotid artery stenting for high-grade carotid artery disease and subsequent reintervention for severe stent restenosis, determining neurological deficit. FCCM diagnosis was made due to the presence of hundreds of cavernous malformations located both in supra- and sub-tentorial regions highlighted by magnetic resonance and confirmed by genetic test for the mutation of the gene KRIT1, inherited also by his son.

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Article Synopsis
  • COVID-19 patients have a high risk of developing serious blood clot complications, including venous and arterial issues.
  • Many patients are quarantined at home, which can complicate timely identification and treatment of these complications, such as Acute limb ischemia (ALI).
  • This text discusses three cases of COVID-19 patients who experienced ALI during home isolation and highlights delays in their diagnosis and treatment resulting from the social impacts of the pandemic.
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  • An abdominal aortic aneurysm (AAA) is a dangerous swelling in the abdominal aorta that can rupture, requiring treatment if it exceeds 5 cm in diameter.
  • The EVAR (Endovascular Aneurysm Repair) is a less invasive procedure that uses a stent graft to treat aortic diseases without directly operating on the aorta.
  • Recent advancements include polymer technologies like the Nellix stent graft (using polymer-filled endobags) and the Ovation stent graft (using an O-ring sealing device), with the latter showing safe and effective results for sealing the aneurysmal neck, whereas the former struggled due to fixation issues.
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Introduction: Device fracture causing intravascular foreign body (IFB) is a rare event during endovascular procedures, with potential catastrophic outcome if not promptly removed. We present two cases of retrieval of fractured devices during peripheral lower limb procedures using three guidewires tangled around the IFB.

Techniques: Case 1 was a patient with critical limb ischemia.

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Objective: Acute limb ischaemia is still considered a significant event, with considerable early- and long-term amputation and mortality risk. Our study aims to investigate the predictive role of pre-operative neutrophil/lymphocyte and platelet/lymphocyte ratios in terms of mortality and amputation risk in patients with acute limb ischaemia.

Methods: Pre-operative blood samples of all patients admitted with acute limb ischaemia were used to calculate neutrophil/lymphocyte and platelet/lymphocyte ratios.

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The role of carotid revascularization in women remains intensely debated because of the lower benefit and higher perioperative risks concerning the male counterpart. Carotid artery endarterectomy (CEA) and stenting (CAS) represent the two most valuable stroke prevention techniques due to large vessel disease. This study investigates the early and late outcomes in female sex in a real-world everyday clinical practice.

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Background: The novel acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic imposed a national lockdown at the beginning of 2020. People faced social distancing, being forced to stay at home. Peripheral arterial disease (PAD) typically influences life habits and psycho-social relationship.

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Objective: The aim was to evaluate the short term safety and effectiveness of the Penumbra/Indigo aspiration thrombectomy Systems (Penumbra Inc.) in patients with acute lower limb ischaemia. (ALLI).

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We evaluated the outcomes of revascularization in patients with chronic limb-threatening ischemia (CLTI) treated in real-world settings. This is a prospective multicenter cohort study with 12-month follow-up enrolling patients (n = 287) with CLTI undergoing open, endovascular, or hybrid lower extremity revascularization. The primary end point was amputation-free survival (AFS) at 12 months.

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